Examinando por Autor "Bautista Amorocho, Henry"
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- PublicaciónAcceso abiertoAbsence of hepatitis C infection among illegal drug users in Bucaramanga, Colombia(2011-01) Bautista Amorocho, Henry; Jaimes Moreno, Brigitte Zorelly; Hincapié López, Martha-LucíaThe aim of this study was to estimate the prevalence of hepatitis C virus (HCV) and identify risk factors associated with the transmission this virus among drug users. In 2009 we performed a cross-sectional study at three facilities handling cases of drug addiction and in one prison. 259 participants were interviewed to collect socio-demographic information and determine risk factors. Anti-HCV antibodies were identified with two different immunoassays. HCV prevalence was 0%. 98% of participants used illegal drugs either orally or nasally while 4.2% injected drugs. 78% of participants reported marijuana consumption, 51% reported consumption of bazuco (Colombian variant of crack cocaine), 50.2% reported cocaine consumption and 22.8% reported amphetamine consumption. 59% had consumed drugs for more than 5 years, 60.2% had tattoos, 17.8% had piercings, and 84.9% have practiced unsafe sex. HCV prevalence was lower than reported in previous studies of drug users in Latin-America. However, we identified risk factors that would facilitate HCV infection once the virus is introduced in this population.
- PublicaciónAcceso abiertoDiseño de un modelo de cáncer gástrico en ratones scid mediante ingeniería genética de células normales de mucosa gástrica humana: Avances(Iatreia, Universidad de Antioquia, 2019-08-15) Bautista Amorocho, Henry; Pérez-Cala, Tania Liseth; Silva-Sayago, Jorge Alexander; Martínez, Alonso; CLINIUDES
- PublicaciónAcceso abiertoEpidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance(2014-12-02) Bautista Amorocho, Henry; Castellanos Domínguez, Yeny Zulay; Rodríguez Villamizar, Laura Andrea; Velandia Cruz, Sindi Alejandra; Becerra Peña, Jeysson Andrey; Farfán García, Ana ElviraAbstract Introduction: Chronic hepatitis B virus (HBV) infection is an increasing cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected individuals. HIV-positive patients are commonly co-infected with HBV due to shared routes of transmission. Objectives: Our aim was to determine the risk factors, prevalence, genotypes, and mutations of the Surface S gene of HBV, and occult hepatitis B infection (OBI) among patients infected with HIV in a northeastern Colombian city. Methods: A cross-sectional study was conducted with 275 HIV-positive patients attending an outpatient clinic in Bucaramanga, Colombia during 2009–2010. Blood samples were collected and screened for serological markers of HBV (anti-HBs, anti-HBc and HBsAg) through ELISA assay. Regardless of their serological profile, all samples were tested for the HBV S gene by nested-PCR and HBV genotypes were determined by phylogenetic inference. Clinical records were used to examine demographic, clinical, virological, immunological and antiretroviral therapy (ART) variables of HIV infection. Results: Participants were on average 37¡11 years old and 65.1% male. The prevalence of HIV-HBV coinfection was 12% (95%CI 8.4–16.4) of which 3.3% had active HBV infection and 8.7% OBI. The prevalence of HIV-HBV coinfection was associated with AIDS stage and ART treatment. Sequence analysis identifiedgenotype F, subgenotype F3 in 93.8% of patients and genotype A in 6.2% of patients. A C149R mutation, which may have resulted from failure in HBsAg detection, was found in one patient with OBI. Conclusions: The present study found a high prevalence of HIV-HBV coinfection with an incidence of OBI 2.6-fold higher compared to active HBV infection. These findings suggest including HBV DNA testing to detect OBI in addition to screening for HBV serological markers in HIV patients.
- PublicaciónAcceso abiertoEtiología y susceptibilidad bacteriana a los antimicrobianos en niños con infecciones urinarias(2009-03) Bautista Amorocho, Henry; Suárez Fragozo, Nailibeth Dayan; Támara Urrutia, Ana Milena; Rodríguez Villamizar, Laura AndreaObjetivo. Conocer la frecuencia de bacterias asociadas a infecciones urinarias y el patrón de susceptibilidad en niños. Material y métodos. A 603 niños que a lo largo de 12 meses los médicos tuvieron la sospecha clínica de infección en las vías urinaria (IVU) se les obtuvo una muestra de orina para estudio bacteriológico y determinación de la susceptibilidad bacteriana a los antibióticos. Resultados. En 212 (35%) de los niños se confirmó el diagnóstico de IVU y la Escherichia coli se encontró en 144 (66%) de éstos, el Proteus sp ocupó el segundo lugar con 36 (17%). Se encontró una resistencia antimicrobiana mayor de 50% para amoxilina, cotrimoxazol y cefalotina. Conclusiones. Como en otros estudios la Escherichia coli es la bacteria más frecuentemente asociada con las IVU, por lo que se deben emplear cefaloesporinas de segunda generación, aminoglucósidos y fluoroquinonas, antimicrobianos para los que fueron sensibles.
- PublicaciónAcceso abiertoMarcadores serológicos y moleculares de infección por el virus de la hepatitis B en estudiantes universitarios colombianos(2012-10) Bautista Amorocho, Henry; Castellanos Domínguez, Yeny Zulay; Farfán García, Ana ElviraIntroduction: Reports from the World Health Organization (WHO) show that the prevalence of hepatitis B virus (HBV) infections varies by geographical region and risk group. Purpose: The purpose of this study was to determine the prevalence of HBV infections, as well as the vaccination status, among university students from Bucaramanga. Methodology: This was a cross sectional study conducted in 2010 which included 1298 students from five universities. Serological markers for HBV infection were detected using ELISA. Viral genomes were detected with nested polymerase chain reaction (PCR). Results: Active infections were established in 0.15% of the study population, and this finding was confirmed by PCR. Resolved infections were identified in 0.60% of the population. Isolated anti-HBc antibodies were found, 30.2% of vaccinated individuals. 67.9% of the study population was susceptible. No occult HBV was detected. Conclusions: The low prevalence of HBV infections reported in this study contrasts with the intermediate epidemiological pattern described in the region. We found poor vaccination coverage and absence of occult hepatitis B among these university students.