Examinando por Autor "Cachofeiro, Victoria"

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  • Publicación
    Restringido
    Inflammation but not endothelial dysfunction is associated with the severity of coronary artery disease in dyslipidemic subjects
    (2009-04) Rueda Clausen, Christian F.; Lopez-Jaramillo, Patricio; Luengas, Carlos; Oubiña, Maria del Pilar; Cachofeiro, Victoria; Lahera, Vicente
    Endothelial dysfunction and inflammation play a key role in the development of atherosclerosis. The present study evaluated endothelial function, inflammatory parameters, and carotid intima-media thickness (IMT) in dyslipidemic patients with or without coronary artery disease (CAD). Methods. Metabolic profile and inflammatory parameters were determined in dyslipidemic patients with (+CAD, n = 33) and without (−CAD, n = 69) symptomatic CAD. Endothelial function was evaluated by flow mediated dilatation (FMD) and plasma concentration of nitrites and nitrates. Carotid IMT was measured by ultrasound. Results. No significant differences were observed in anthropometric hemodynamic or metabolic parameters between the groups. After adjusting by age and medication usage, some inflammatory markers were significantly higher in +CAD; however. no significant differences in FMD or plasma levels of nitrites were observed. Conclusions. In subjects with dyslipidemia, the presence of CAD is associated with an elevation of certain inflammatory markers and carotid IMT but not with further endothelial dysfunction.
  • Publicación
    Acceso abierto
    The presence of abdominal obesity is associated with changes in vascular function independently of other cardiovascular risk factors
    (2010) Rueda Clausen, Christian F.; Lahera, Vicente; Calderón, Jaime; Bolivar, Isabel Cristina; Castillo, Victor R.; Gutiérrez, Melquisedec; Carreño, Marisol; Oubiña, Maria del Pilar; Cachofeiro, Victoria; Lopez-Jaramillo, Patricio
    Background: Because of the strong association between abdominal obesity (AO) and other cardiovascular risk factors, it has been difficult to determine which changes in vascular function are directly related to this condition. Our objective was to evaluate the changes in ex-vivo vascular reactivity, circulating levels of adipokines and inflammatory markers associated with the presence of AO in subjects who underwent coronary artery bypass graft (CABG) controlling by the presence of other cardiovascular risk factors. Methods: Subjects scheduled for a CABG with (n=17) and without (n=17) AO (defined as a waist circumference ≥90 cm for male or ≥80 cm for female) whom were matched by several cardiovascular risk factors, were included in the study. Lipid profile and plasma levels of glucose, insulin, leptin, adiponectin and inflammatory markers were measured. Internal mammary artery segments were used for ex-vivo vascular reactivity experiments and morphometry. Results: Leptin concentrations were higher and adiponectin concentrations were lower in subjects with AO. No differences were observed in other biochemical or clinical parameters between the groups. No correlation between waist circumference, HOMA index and inflammatory markers were observed. Endothelium-dependent relaxation to acetylcholine was lower, and contractile responses to angiotensin-II were higher in subjects with AO. These changes were not related to differences in vascular morphometry. Conclusion: In subjects with severe coronary disease, the presence of AO was associated with leptin/adiponectin imbalance, decreased endothelium-dependent relaxation and an enhanced response to angiotensin-II. These changes occurred independently of other cardiovascular risk factors including insulin resistance and levels of inflammatory markers.