Examinando por Autor "Gómez Rave, Liz J."
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- PublicaciónAcceso abiertoAlteraciones tiroideas en diabetes mellitus tipo 2 - Thyroid alterations in type 2 diabetes mellitus(Revista Latinoamericana de Hipersensible, 2019-10-01) Sierra-Castrillo, J.; Gómez Rave, Liz J.; Chacín-González, M.; Quintero, JR; Bermúdez Pirela, ValmoreDiabetes mellitus is one of the world’s leading non-communicable diseases. It leads to alterations in glucose metabolism due to the low availability of insulin or resistance to its action. Recent studies indicate that there is a relationship between diabetes mellitus and thyroid dysfunction, mediated by disturbances in the hypothalamus - pituitary - thyroid axis, and reduced deiodinase activity, synergism of mitogenic routes, increased inflammatory status, oxi-dative stress and insulin resistance. The most frequent alteration is subclinical hypothyroidism and it occurs more frequently in women, so it is suggested to periodically perform the thyroid profile to these patients. It is necessary that in clinical practice these implications are taken into account in order to provide timely treatment, improve complications such as cardiovascular disease and reduce morbidity and mortality rates.
- PublicaciónAcceso abiertoAsociación de los niveles de adiponectina y del factor de necrosis tumoral alfa con albuminuria en pacientes con diabetes tipo 2(2017) Sierra Castrillo, Jhoalmis.; Gómez Rave, Liz J.Type 2 Diabetes mellitus is a metabolic chronic disease, which if it is not properly controlled produces a progressive kidney damage causing diabetc nephropathy. It is also highly associated with a chronic infammatory state, related to adipocytokines (IL-6, TNF-α, leptn, adiponectn) secreton which are involved in metabolic homeostasis and crucial in both regulatng the atherogenic process as in insulin resistance. Objectve: To relate the behavior of adiponectn and TNF-α levels with albumi- nuria in patents with type 2 diabetes mellitus. Materials and methods: The research was based on a descriptve cross-sectonal model with a study populaton composed by patents admited to University Hospital Erasmo Meoz (Cucuta, Colombia). According to previously established selecton criteria, two analysis groups were conformed; patents diagnosed with type 2 diabetes mellitus and albuminuria >30 mg/L (n = 24), and a control group without the above conditons (n = 20). Results: The results revealed that there is a positve and statstcally signifcant correlaton between TNF-α concentraton and albuminuria (p <0.03). It was observed that between TNF-α and adiponectn levels there are no apparently correlaton (p> 0.05). Conclusions: although there are no signifcant diferences between adiponectn and TNF-α levels, TNF-α could be exploited as an early markers for kidney damage or help designing of progression estmators of injury in patents with diabetes type 2.