Examinando por Autor "Hernández-Gamboa, Adriana E."
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- PublicaciónAcceso abiertoEtiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia.(San Francisco : Plos One, 2020., 2020-06-30) Farfán García, Ana Elvira; Imdad, Aamer; Zhang, Chengxian; Arias Guerrero, Monica Y.; Sánchez Álvarez, Nayibe T.; Iqbal, Junaid; Hernández-Gamboa, Adriana E.; Slaughter, James C.; Gómez-Duarte, Oscar G.; Universidad de Santander; Abiola Senok, Mohammed Bin RashidLa gastroenteritis aguda (GEA) es una de las principales causas de mortalidad en niños menores de 5 años en países de ingresos bajos y medianos (PIBM). La mayor carga de la enfermedad AGE se concentra en áreas tropicales donde las poblaciones carecen de acceso a agua potable, saneamiento e higiene adecuados, lo que hace que esta afección sea una enfermedad desatendida. La información limitada sobre la etiología, la desnutrición asociada y la mortalidad entre las comunidades desatendidas dificulta el desarrollo de estrategias para la prevención y el tratamiento de los AGE. Este estudio de casos y controles en niños menores de 5 años en Bucaramanga, Colombia, reveló que los organismos virales seguidos de bacterias explicaron la mayor proporción de AGE, siendo el norovirus el organismo más común. La mayor tasa de infecciones y coinfecciones entre los casos en comparación con los controles se asoció con AGE.E . coli entre los casos designados como E enteroinvasores formadores de biopelículas . coli (BF-EIEC), E enteroagregativa / enteropatógena . coli y E. enteroagregativa / enterotoxigénica . coli (EAEC / ETEC).
- PublicaciónAcceso abiertoEtiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study(PLOS Neglected Tropical Diseases, 2020-06-30) Farfán García, Ana Elvira; Imdad, Aamer; Zhang, Chengxian; Arias Guerrero, Monica Y.; Sánchez Álvarez, Nayibe T.; Iqbal, Junaid; Hernández-Gamboa, Adriana E.; Slaughter, James C.; Gómez Duarte, Oscar Gilberto; CLINIUDESBackground Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children aged less than 5 years in low- and middle-income countries where limited access to potable water, poor sanitation, deficient hygiene, and food product contamination are prevalent. Research on the changing etiology of AGE and associated risk factors in Latin America, including Colombia, is essential to understand the epidemiology of these infections. The primary objectives of this study were to describe etiology of moderate to severe AGE in children less than 5 years of age from Bucaramanga, Colombia, a middle-income country in Latin American, and to identify the presence of emerging E. coli pathotypes. Methodology/Principal findings This was a prospective, matched for age, case-control study to assess the etiology of moderate to severe AGE in children less than 5 years of age in Bucaramanga, Colombia, South America. We tested for 24 pathogens using locally available diagnostic testing, including stool culture, polymerase chain reaction, microscopy and enzyme-linked immunoassay. Adjusted attributable fractions were calculated to assess the association between AGE and each pathogen in this study population. The study included 861 participants, 431 cases and 430 controls. Enteric pathogens were detected in 71% of cases and in 54% of controls (p = <0.001). Co-infection was identified in 28% of cases and in 14% of controls (p = <0.001). The adjusted attributable fraction showed that Norovirus GII explained 14% (95% CI: 10–18%) of AGE, followed by rotavirus 9.3% (6.4–12%), adenovirus 3% (1–4%), astrovirus 2.9% (0.6–5%), enterotoxigenic Escherichia coli (ETEC) 2.4% (0.4–4%), Cryptosporidium sp. 2% (0.5–4%), Campylobacter sp. 2% (0.2–4%), and Salmonella sp.1.9% (0.3 to 3.5%). Except for Cryptosporidium, all parasite infections were not associated with AGE. Three emergent diarrheagenic E. coli pathotypes were identified in cases (0.7%), including an enteroaggregative/enterotoxigenic E.coli (EAEC/ETEC), an enteroaggregative/enteropathogenic E.coli (EAEC/EPEC), and an emergent enteroinvasive E. coli with a rare O96:H19. No deaths were reported among cases or controls. Conclusions/Significance Norovirus and rotavirus explained the major proportion of moderate to severe AGE in this study. Higher proportion of infection in cases, in the form of single infections or co-infections, showed association with AGE. Three novel E. coli pathotypes were identified among cases in this geographic region.