Examinando por Autor "Lakshmi, P. V. M."
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- PublicaciónAcceso abiertoAssociation of Sitting Time with Mortality and Cardiovascular Events in High-Income, Middle-Income, and Low-Income Countries(2022-06-15) Li, Sidong; Lear, Scott A.; Rangarajan, Sumathy; Hu, Bo; Yin, Lu; Bangdiwala, Shrikant I.; Alhabib, Khalid F.; Rosengren, Annika; Gupta, Rajeev; Mony, Prem K.; Wielgosz, Andreas; Rahman, Omar; Mazapuspavina, M. Y.; Avezum, Alvaro; Oguz, Aytekin; Yeates, Karen; Lanas, Fernando; Dans, Antonio; Evans, Marc; Abat, M.; Yusufali, Afzalhussein; Rafael, Diaz; Lopez-Jaramillo, Patricio; Leach, Lloyd; Lakshmi, P. V. M.; Iqbal, Romaina; Kelishadi, Roya; Chifamba, Jephat; Khatib, Rasha; Li, Wei; Yusuf, Salim; MasiraImportance High amounts of sitting time are associated with increased risks of cardiovascular disease (CVD) and mortality in high-income countries, but it is unknown whether risks also increase in low- and middle-income countries. Objective To investigate the association of sitting time with mortality and major CVD in countries at different economic levels using data from the Prospective Urban Rural Epidemiology study. Design, Setting, and Participants This population-based cohort study included participants aged 35 to 70 years recruited from January 1, 2003, and followed up until August 31, 2021, in 21 high-income, middle-income, and low-income countries with a median follow-up of 11.1 years. Exposures Daily sitting time measured using the International Physical Activity Questionnaire. Main Outcomes and Measures The composite of all-cause mortality and major CVD (defined as cardiovascular death, myocardial infarction, stroke, or heart failure). Results Of 105 677 participants, 61 925 (58.6%) were women, and the mean (SD) age was 50.4 (9.6) years. During a median follow-up of 11.1 (IQR, 8.6-12.2) years, 6233 deaths and 5696 major cardiovascular events (2349 myocardial infarctions, 2966 strokes, 671 heart failure, and 1792 cardiovascular deaths) were documented. Compared with the reference group (<4 hours per day of sitting), higher sitting time (≥8 hours per day) was associated with an increased risk of the composite outcome (hazard ratio [HR], 1.19; 95% CI, 1.11-1.28; Pfor trend < .001), all-cause mortality (HR, 1.20; 95% CI, 1.10-1.31; Pfor trend < .001), and major CVD (HR, 1.21; 95% CI, 1.10-1.34; Pfor trend < .001). When stratified by country income levels, the association of sitting time with the composite outcome was stronger in low-income and lower-middle–income countries (≥8 hours per day: HR, 1.29; 95% CI, 1.16-1.44) compared with high-income and upper-middle–income countries (HR, 1.08; 95% CI, 0.98-1.19; P for interaction = .02). Compared with those who reported sitting time less than 4 hours per day and high physical activity level, participants who sat for 8 or more hours per day experienced a 17% to 50% higher associated risk of the composite outcome across physical activity levels; and the risk was attenuated along with increased physical activity levels. Conclusions and Relevance High amounts of sitting time were associated with increased risk of all-cause mortality and CVD in economically diverse settings, especially in low-income and lower-middle–income countries. Reducing sedentary time along with increasing physical activity might be an important strategy for easing the global burden of premature deaths and CVD.
- PublicaciónAcceso abiertoAssociation of ultra-processed food intake with risk of inflammatory bowel disease. Prospective cohort study(BMJ Journals, 2021-07-14) Narula, Neeraj; Wong, Emily C.L.; Dehghan, Mahshid; Mente, Andrew; Rangarajan, Sumathy; Lanas, Fernando; Lopez-Jaramillo, Patricio; Rohatgi, Priyanka; Lakshmi, P. V. M.; Prasad Varma, Ravi; Orlandini, Andres; Avezum, Alvaro; Wielgosz, Andreas; Poirier, Paul; Almadi, Majid A.; Altuntas, Yuksel; Ng, Kien Keat; Chifamba, Jephat; Yeates, Karen; Puoane, Thandi; Khatib, Rasha; Yusuf, Rita; Bengtsson Boström, Kristina; Zatonska, Katarzyna; Iqbal, Romaina; Weida, Liu; Yibing, Zhu; Sidong, Li; Dans, Antonio; Yusufali, Afzalhussein; Mohammadifard, Noushin; Marshall, John K.; Moayyedi, Paul; Reinisch, Walter; Yusuf, Salim; MasiraOBJECTIVE To evaluate the relation between intake of ultraprocessed food and risk of inflammatory bowel disease (IBD). DESIGN Prospective cohort study. SETTING 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle East, south Asia, South East Asia, and China). PARTICIPANTS 116087 adults aged 35-70 years with at least one cycle of follow-up and complete baseline food frequency questionnaire (FFQ) data (country specific validated FFQs were used to document baseline dietary intake). Participants were followed prospectively at least every three years. MAIN OUTCOME MEASURES The main outcome was development of IBD, including Crohn’s disease or ulcerative colitis. Associations between ultra-processed food intake and risk of IBD were assessed using Cox proportional hazard multivariable models. Results are presented as hazard ratios with 95% confidence intervals. RESULTS Participants were enrolled in the study between 2003 and 2016. During the median follow-up of 9.7 years (interquartile range 8.9-11.2 years), 467 participants developed incident IBD (90 with Crohn’s disease and 377 with ulcerative colitis). After adjustment for potential confounding factors, higher intake of ultra-processed food was associated with a higher risk of incident IBD (hazard ratio 1.82, 95% confidence interval 1.22 to 2.72 for ≥5 servings/day and 1.67, 1.18 to 2.37 for 1-4 servings/day compared with <1 serving/day, P=0.006 for trend). Different subgroups of ultra-processed food, including soft drinks, refined sweetened foods, salty snacks, and processed meat, each were associated with higher hazard ratios for IBD. Results were consistent for Crohn’s disease and ulcerative colitis with low heterogeneity. Intakes of white meat, red meat, dairy, starch, and fruit, vegetables, and legumes were not associated with incident IBD. CONCLUSIONS Higher intake of ultra-processed food was positively associated with risk of IBD. Further studies are needed to identify the contributory factors within ultraprocessed foods. STUDY REGISTRATION ClinicalTrials.gov NCT03225586.
- PublicaciónAcceso abiertoHousehold and personal air pollution exposure measurements from 120 communities in eight countries(The Lancet Planetary Health, 2020-10-01) Shupler, Matthew; Hystad, Perry; Birch, Aaron; Miller-Lionberg, Daniel; Jeronimo, Matthew; Arku, Raphael E.; Chu, Yen Li; Mushtaha, Maha; Heenan, Laura; Rangarajan, Sumathy; Seron, Pamela; Lanas, Fernando; Cazor, Fairuz; Lopez-Jaramillo, Patricio; Camacho López, Paul Anthony; Perez, Maritza; Yeates, Karen; West, Nicola; Ncube, Tatenda; Ncube, Brian; Chifamba, Jephat; Yusuf, Rita; Khan, Afreen; Hu, Bo; Liu, Xiaoyun; Wei, Li; Tse, Lap Ah; Mohan, Deepa; Kumar, Parthiban; Gupta, Rajeev; Mohan, Indu; Jayachitra, K. G.; Mony, Prem K.; Rammohan, Kamala; Nair, Sanjeev; Lakshmi, P. V. M.; Sagar, Vivek; Khawaja, Rehman; Iqbal, Romaina; Kazmi, Khawar; Yusuf, Salim; Brauer, Michael; thePURE-AIR study; EverestBackground Approximately 2·8 billion people are exposed to household air pollution from cooking with polluting fuels. Few monitoring studies have systematically measured health-damaging air pollutant (ie, fine particulate matter [PM2·5] and black carbon) concentrations from a wide range of cooking fuels across diverse populations. This multinational study aimed to assess the magnitude of kitchen concentrations and personal exposures to PM2·5 and black carbon in rural communities with a wide range of cooking environments. Methods As part of the Prospective Urban and Rural Epidemiological (PURE) cohort, the PURE-AIR study was done in 120 rural communities in eight countries (Bangladesh, Chile, China, Colombia, India, Pakistan, Tanzania, and Zimbabwe). Data were collected from 2541 households and from 998 individuals (442 men and 556 women). Gravimetric (or filter-based) 48 h kitchen and personal PM2·5 measurements were collected. Light absorbance (10− ⁵m− ¹) of the PM2·5 filters, a proxy for black carbon concentrations, was calculated via an image-based reflectance method. Surveys of household characteristics and cooking patterns were collected before and after the 48 h monitoring period. Findings Monitoring of household air pollution for the PURE-AIR study was done from June, 2017, to September, 2019. A mean PM2·5 kitchen concentration gradient emerged across primary cooking fuels: gas (45 μg/m³ [95% CI 43–48]), electricity (53 μg/m³ [47–60]), coal (68 μg/m³ [61–77]), charcoal (92 μg/m³ [58–146]), agricultural or crop waste (106 μg/m³ [91–125]), wood (109 μg/m³ [102–118]), animal dung (224 μg/m³ [197–254]), and shrubs or grass (276 μg/m³ [223–342]). Among households cooking primarily with wood, average PM2·5 concentrations varied ten-fold (range: 40–380 μg/m³). Fuel stacking was prevalent (981 [39%] of 2541 households); using wood as a primary cooking fuel with clean secondary cooking fuels (eg, gas) was associated with 50% lower PM2·5 and black carbon concentrations than using only wood as a primary cooking fuel. Similar average PM2·5 personal exposures between women (67 μg/m³ [95% CI 62–72]) and men (62 [58–67]) were observed. Nearly equivalent average personal exposure to kitchen exposure ratios were observed for PM2·5 (0·79 [95% 0·71–0·88] for men and 0·82 [0·74–0·91] for women) and black carbon (0·64 [0·45–0·92] for men and 0·68 [0·46–1·02] for women). Interpretation Using clean primary fuels substantially lowers kitchen PM2·5 concentrations. Importantly, average kitchen and personal PM2·5 measurements for all primary fuel types exceeded WHO’s Interim Target-1 (35 μg/m³ annual average), highlighting the need for comprehensive pollution mitigation strategies.