Examinando por Autor "Rizzo Sierra, Carlos V."
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- PublicaciónAcceso abiertoCorrigendum to "A new neurometric dissection of the area-under-curve-associated jiggle of the motor evoked potential induced by transcranial magnetic stimulation"(2015-12-01) Leon-Sarmiento, Fidias E.; Rizzo Sierra, Carlos V.; Leon-Ariza, Juan S.; Leon-Ariza, Daniel S.; Sobota, Rosanna; Prada, Diddier G.
- PublicaciónAcceso abiertoA necklace sonar with adjustable scope range for assisting the visually impaired(2013) Villamizar, Luz H.; Gualdrón, Mauricio; González, Fabio; Aceros, Juan; Rizzo Sierra, Carlos V.A sonar based device with tactile feedback was developed to improve the mobility and independence of visually impaired individuals. It features a transceiver/receiver, a potentiometer, a microcontroller, a rechargeable polymer lithium ion battery, and a Nokia Cell phone vibrator. All components are commercially available and housed in a custom acrylic package with 86 mm × 34 mm × 12 mm in dimension, and 120 grms in weight. Additionally, the device features an adjustable detection scheme for user customization of distance range, and a tactile feedback system that avoids interference with auditory sensory information. The device was tested for its navigational efficacy in an artificial indoor environment, and in a live outdoor setting. Ten subjects (9 males and 1 female), with a mean age of 35 years-old (range: 17 to 52) were presented with a series of navigational tasks resulting in considerable reduction of head, shoulder, chest, and arms collisions during their locomotion. We conclude that this device greatly improves the mobility and safety of visually impaired individuals.
- PublicaciónAcceso abiertoA new neurometric dissection of the area-under-curve-associated jiggle of the motor evoked potential induced by transcranial magnetic stimulation(2015-02-14) Leon-Sarmiento, Fidias E.; Rizzo Sierra, Carlos V.; Leon-Ariza, Juan S.; Leon-Ariza, Daniel S.; Sobota, Rosanna; Prada, Diddier G.Objective The jiggle of the motor evoked potential (MEP) induced by transcranial magnetic stimulation (TMS) depends on a number of factors including the assessment of this stochastic signal by the method known as area under curve (AUC). We aim to ascertain the MEP findings assessed by the AUC method obtained from individuals affected by lesions at different levels of the neuroaxis. Methods We systematically search and critically appraise the scientific reports publishing on the MEP obtained from individuals with hypo- or hyperkinetic disorders of the neural system, and dissect the neurophysical assessment of the obtained data. To accomplish this, we used the instruments named to as U-Pen Instrument for Neurometric Evaluation Uncommonly and Rarely Obtained from NeuroSignals 1.0 (UPINEURON 1.0), and the Quality of Assessment Statistics Index (QuASI). Results The MEP differences found by the classical peak-to-peak method decreased or disappeared when the AUC was used. The opposite was also true (Kappa = < 0.00). The internal consistency of the UPINEURON was 0.88. The mean of the UPINEURON 1.0 indicator was 34.8 (range = 16–50), and the mean of the QuASI scores was 56.5 (range 30–80). Spearman correlation between UPINEURON 1.0 and QuASI was 0.513. Conclusions The MEP jiggle found in individuals with disordered neural function is not a “minor” factor; it is beyond the underlying neural condition, sample size, type of coils, and number of trials, among other variables. The use of the novel indicators introduced in this investigation will help to improve the analysis of the AUC of neural signals. They may also lead to the reconsideration of current practices.
- PublicaciónAcceso abiertoSensory aspects in myasthenia gravis : A translational approach(2016-09-15) Leon-Sarmiento, Fidias E.; Leon-Ariza, Juan S.; Prada, Diddier G.; Leon-Ariza, Daniel S.; Rizzo Sierra, Carlos V.Myasthenia gravis is a paradigmatic muscle disorder characterized by abnormal fatigue and muscle weakness that worsens with activities and improves with rest. Clinical and research studies done on nicotinic acetylcholine receptors have advanced our knowledge of the muscle involvement in myasthenia. Current views still state that sensory deficits are not “features of myasthenia gravis”. This article discusses the gap that exists on sensory neural transmission in myasthenia that has remained after > 300 years of research in this neurological disorder. We outline the neurobiological characteristics of sensory and motor synapses, reinterpret the nanocholinergic commonalities that exist in both sensory and motor pathways, discuss the clinical findings on altered sensory pathways in myasthenia, and propose a novel way to score anomalies resulting from multineuronal inability associated sensory troubles due to eugenic nanocholinergic instability and autoimmunity. This medicine-based evidence could serve as a template to further identify novel targets for studying new medications that may offer a better therapeutic benefit in both sensory and motor dysfunction for patients. Importantly, this review may help to re-orient current practices in myasthenia.