Examinando D. Vicerrectoría de Investigaciones por Materia "Abdominal obesity"
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- PublicaciónRestringidoHigher household income and the availability of electronic devices and transport at home are associated with higher waist circumference in Colombian children : The ACFIES study(2014-02) Gómez Arbeláez, Diego; Camacho López, Paul Anthony; Cohen, Daniel Dylan; Rincón Romero, Katherine; Alvarado Jurado, Laura; Pinzón, Sandra; Duperly, John; Lopez-Jaramillo, PatricioBackground: The current “epidemic” of childhood obesity is described as being driven by modern lifestyles with associated socioeconomic and environmental changes that modify dietary habits, discourage physical activity and encourage sedentary behaviors. Objective: To evaluate the association between household income and the availability of electronic devices and transport at home, and the values of waist circumference (WC), as an indicator of abdominal obesity, in children and adolescents from Bucaramanga, Colombia. Methods: Cross-sectional study of public elementary and high school population, of low-middle socioeconomic status. Results: A total of 668 schoolchildren were recruited. After adjusting for potential confounders, significant positive associations between waist circumference and higher household income (p = 0.011), and waist circumference and the availability of electronic devices and transport at home (p = 0.026) were found. Conclusions: In low-middle socioeconomic status schoolchildren in a developing country, those from relatively more affluent families had greater waist circumference, an association that is opposite to that observed in developed countries. This finding could be related to higher income family’s ability to purchase electronic devices and motorized transport which discourage physical activity and for their children to buy desirable and more costly western fast food.
- PublicaciónRestringidoLecciones aprendidas de dos grandes estudios epidemiológicos de enfermedades cardio-cerebrovasculares en las que ha participado Colombia(2010-09) Lopez-Jaramillo, Patricio; López López, JoseDos recientes estudios epidemiológicos de gran envergadura en los que participó Colombia, elINTERHEART y el INTERSTROKE, demostraron que en Latinoamérica en general y en Colombia en particular,el principal factor de riesgo para la presentación de infarto agudo del miocardio y accidente cerebro vascularisquémico y hemorrágico es la obesidad abdominal, a diferencia del resto del mundo donde el principal factorde riesgo fue el aumento en las concentraciones plasmáticas del colesterol total y del colesterol LDL, en elprimer caso, y la hipertensión arterial, en el segundo. Estos datos dan soporte a la propuesta de que enLatinoamérica la transición rápida de los modelos económicos experimentados en los últimos años junto conla urbanización acelerada son la causa del explosivo aumento de la obesidad abdominal, la diabetes mellitustipo 2 y las enfermedades cardio-cerebro-vasculares.
- PublicaciónAcceso abiertoThe presence of abdominal obesity is associated with changes in vascular function independently of other cardiovascular risk factors(2010) Rueda Clausen, Christian F.; Lahera, Vicente; Calderón, Jaime; Bolivar, Isabel Cristina; Castillo, Victor R.; Gutiérrez, Melquisedec; Carreño, Marisol; Oubiña, Maria del Pilar; Cachofeiro, Victoria; Lopez-Jaramillo, PatricioBackground: Because of the strong association between abdominal obesity (AO) and other cardiovascular risk factors, it has been difficult to determine which changes in vascular function are directly related to this condition. Our objective was to evaluate the changes in ex-vivo vascular reactivity, circulating levels of adipokines and inflammatory markers associated with the presence of AO in subjects who underwent coronary artery bypass graft (CABG) controlling by the presence of other cardiovascular risk factors. Methods: Subjects scheduled for a CABG with (n=17) and without (n=17) AO (defined as a waist circumference ≥90 cm for male or ≥80 cm for female) whom were matched by several cardiovascular risk factors, were included in the study. Lipid profile and plasma levels of glucose, insulin, leptin, adiponectin and inflammatory markers were measured. Internal mammary artery segments were used for ex-vivo vascular reactivity experiments and morphometry. Results: Leptin concentrations were higher and adiponectin concentrations were lower in subjects with AO. No differences were observed in other biochemical or clinical parameters between the groups. No correlation between waist circumference, HOMA index and inflammatory markers were observed. Endothelium-dependent relaxation to acetylcholine was lower, and contractile responses to angiotensin-II were higher in subjects with AO. These changes were not related to differences in vascular morphometry. Conclusion: In subjects with severe coronary disease, the presence of AO was associated with leptin/adiponectin imbalance, decreased endothelium-dependent relaxation and an enhanced response to angiotensin-II. These changes occurred independently of other cardiovascular risk factors including insulin resistance and levels of inflammatory markers.