Examinando por Materia "C-reactive protein"
Mostrando 1 - 5 de 5
Resultados por página
Opciones de clasificación
- PublicaciónAcceso abiertoAsociación entre niveles de proteína C-reactiva y oxido nítrico con el pronostico de pacientes con enfermedad cerebro vascular isquémica(2015-04) García, Ronald G.; Rosso, Pedro; García, Zaira M.; Álvarez Camacho, Julie; Suárez, Uriel; Gómez Arbeláez, Diego; Lopez-Jaramillo, Patricio; Silva Sieger, Federico ArturoIntroduction: Inflammation and alterations in the bioavailability of nitric oxide (NO) have been involved in the pathophysiology of cerebrovascular disease. Objective: The aim of the study was to determine the prognostic value of measuring NO metabolites and inflammatory markers in patients with acute ischemic stroke. Materials and methods: A total of 158 patients with acute ischemic stroke were included in an observational cohort study. Between 48 and 72 hours post admission, a fasting blood sample was taken to determine the biochemical profile, inflammatory markers (CRP, IL1-β, IL6, TNF-α) and nitrites/nitrates plasma levels. The cohort’s follow-up was conducted for two years to determine the occurrence of a new event (stroke, myocardial infarction, heart failure) or death of vascular origin. Comparisons between groups were made using the log-rank test. A Cox multivariate regression analysis permitted to determine factors independently associated with the outcome. Results: The mean age was 70.5 ± 12.8 years. 39.2% of the subjects presented the outcome during the first 24 months of follow-up. CRP levels > 12 mg/L (HR 2.22, 95% CI 1.07-4.59) and a score > 13 on the NIHSS scale at admission (HR 2.81 95% CI 1.46-5.41) were significantly associated with an increased risk of a new event. The combination of CRP levels < 12 mg/L and nitrites/nitrates levels < 35.5 mmol/L was identified as a protective factor (HR 0.21, 95% CI 0.06-0.71). Conclusion: This study demonstrates that the determination of CRP and NOx levels could be beneficial in clinical practice to stratify the risk of future events or death of vascular origin in acute ischemic stroke patients.
- PublicaciónRestringidoDeterminación de los Niveles Séricos de Proteína C Reactiva Ultrasensible Para su Asociación con Factores de Riesgo Cardiovascular en Estudiantes de la Universidad de Santander Campus Valledupar(Univeridad de Santander, 2018-06-01) Pimienta-Brito, Daisanis Mayelis; Gutiérrez-Vega, Katiuska René; Camargo-De La Hoz, LeidyLa obesidad es una enfermedad crónica, multifactorial, caracterizada por la acumulación de tejido adiposo en el organismo, influenciado por factores genéticos y ambientales. Estudios epidemiológicos han demostrado que la obesidad es uno de los principales factores de riesgo mayor de enfermedades cardiovasculares. El objetivo del presente estudio fue determinar los niveles séricos de Proteína C Reactiva Ultrasensible para su asociación con factores de riesgo cardiovascular en estudiantes de la Universidad de Santander Campus Valledupar. El estudio fue desarrollado en 58 estudiantes con edades comprendidas entre los 18 a 30 años. Las variables a tener en cuenta fueron: edad, género, Índice de Masa Corporal (IMC), Circunferencia de Cintura (CC) actividad física, consumo de alcohol, tabaquismo y pruebas bioquímicas como perfil lipídico, glicemia y PCR hs. Se aplicó una encuesta de factores de riesgo y los niveles de PCR fueron determinados por un método de alta sensibilidad. Como resultado se obtuvo que de los 58 pacientes el 29 (50%) del género femenino y 29 (50%) del género masculino con edades entre los 18 y 30 años, la mediana de edad fue de 22.09; se logró determinar que hay una asociación estadísticamente significativa entre el IMC, PCR-hs y CC (<0.000) principalmente en aquellos participantes con sobrepeso y obesidad. Los resultados expresados en este estudio indican, que los jóvenes con sobrepeso y obesidad presentan niveles de PCR más elevado que los jóvenes con normopeso, teniendo esta variable significativa asociación con parámetros antropométricos como el IMC y el CC.
- PublicaciónRestringidoInter-relationships between body mass index, C-reactive protein and blood pressure in a hispanic pediatric population(2009-05) Lopez-Jaramillo, Patricio; Herrera Anaya, Elizabeth; García, Ronald G.; Camacho López, Paul Anthony; Castillo, Victor R.The link between inflammation, obesity, and cardiovascular disease (CVD) has been described in adult populations but few data are available with respect to children. The aim of this study was to describe the inter-relationships between adiposity, C-reactive protein (CRP) plasma concentrations, and blood pressure levels in a Hispanic pediatric population. Methods We included 325 schoolchildren (mean age, 10.0 years) selected from the school population of Bucaramanga, Colombia. Blood pressure, lipid profile, glucose, and CRP plasma concentration were measured using standard procedures. Body mass index (BMI) was used for evaluating the children’s nutritional condition. Correlation coefficients were calculated for all the variables using Spearman’s test. Results As expected, a positive correlation was found between BMI and systolic blood pressure (SBP) in both genders, and between CRP and SBP levels in boys. After a multivariate regression analysis, the association between adiposity and blood pressure remained significant, whereas the CRP concentrations were no longer associated with SBP. Conclusions The results obtained in our study of Hispanic school-age children show that adiposity is correlated with CRP concentrations and SBP values as has been earlier described in Caucasian populations. However, we failed to find a significant relationship between low-grade inflammation and SBP levels. Further studies are needed in order to explore alternative pathophysiological mechanisms linking obesity and high blood pressure in children and to define the impact of these associations on the cardiovascular risk of our pediatric population.
- PublicaciónAcceso abiertoNiveles séricos de marcadores inflamatorios en pacientes hipertensos de la E.S.E. IMSALUD, Cúcuta, Colombia(2015-10-31) Ríos Ramírez, Yesmit Karina; Mendoza Toloza, Sandra M.; Carvajal Ortega, Johanna K.; Taylor Orozco, Viviana MilenaIntroduction: Hypertension is a multifactorial clinical condition characterized by elevated systolic or diastolic blood pressure that it is establishing itself as a major risk factor in the onset of cardiovascular disease. Objectives: To determine serum levels of IFN-γ, TNF-α and C-reactive protein, relating to hypertension in patients attending the E.S.E. Imsalud - Unidad Materno Infantil La Libertad (Cucuta, Colombia). Material and methods: A correlational descriptive study was realized in hypertensive individuals and healthy controls selected through structured survey. Serum levels of IFN-γ and TNF-α were analyzed by ELISA and high-sensitivity C-reactive protein levels by turbidimetric immunoassays.
- PublicaciónAcceso abiertoPeriodontal disease severity is related to high levels of C-reactive protein in pre-eclampsia(2007-07) Herrera, Julián A.; Parra, Beatriz; Herrera, Enrique; Botero, Javier E.; Arce, Roger M.; Contreras, Adolfo; Lopez-Jaramillo, PatricioObjective Recent studies have shown that pre-eclamptic women present a high prevalence of periodontitis, suggesting that active periodontal disease may play a role in the pathogenesis of pre-eclampsia. The present study analysed the effect of periodontal disease in the concentrations of serum high-sensitivity C-reactive protein (hs-CRP), and its association with pre-eclampsia. Methods A case–control study was carried out in Cali-Colombia, comprised of 398 pregnant women (145 cases and 253 controls) who were believed to have periodontal disease, between 28 and 36 weeks of gestational age. Pre-eclampsia cases were defined as blood pressure >– 140/90 mmHg and proteinuria >– 0.3 g/24 h. Controls were pregnant women with normal blood pressure, without proteinuria, matched by maternal age, gestational age and body mass index. Sociodemographic data, obstetric risk factors, periodontal state, subgingival microbial composition and hs-CRP levels were determined in both groups. Results The case and control groups were comparable for sociodemographic characteristics. In women with pre-eclampsia and confirmed periodontal disease (n U 138), hs-CRP levels increased according to the severity of the disease (gingivitis median 4.14 mg/dl; mild periodontitis median 4.70 mg/dl; moderate/severe periodontitis median 8.8 mg/dl; P U 0.01). A similar tendency was observed in controls with periodontal disease (n U 251), but it did not reach statistical significance (gingivitis median 5.10 mg/dl; mild periodontitis median 5.12 mg/dl; moderate/severe periodontitis median 6.90 mg/dl; P U 0.07). A significant difference in hs-CRP levels was observed in pre-eclamptic women with moderate/severe periodontitis compared to controls (P U 0.01). Conclusion These findings suggest that chronic periodontitis may increase hs-CRP levels in pregnant women and lead to complications such as pre-eclampsia.