Examinando por Materia "Dengue virus"
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- PublicaciónRestringidoAsociación de Seroprevalencia y seroconversión de la Respuesta IgG Anti-virus dengue, con el área de formación de estudiantes de primer Semestre de la UDES Cúcuta, Colombia, 2018-2019.(Cúcuta, Universidad de Santander, 2019, 2019-12-11) Parra Galicia, Stephany Andrea; Palacios Yáñez, Sthefany; Cárdenas, Denny Miley; Contreras Rangel, Jael.El virus Dengue, transmitido por insectos del género Aedes sp, causa la mayor arbovirosis del planeta. Norte de Santander, considerado zona endémica, ocupa el quinto puesto a nivel Nacional reportando 6.034 casos. La mayoría de las infecciones son asintomáticas facilitando su no percepción, actualmente no se cuenta con información sobre prevalencia de Dengue en la comunidad UDES, requiriéndose del conocimiento del estado de éste evento infeccioso en nuestra comunidad en fortalecimiento de la vigilancia epidemiológica; por lo cual el presente trabajo propuso determinar la asociación de la respuesta humoral IgG a Flavivirus Dengue en relación con variables sexo, edad y área de formación, en estudiantes de primer semestre de la Universidad de Santander, Cúcuta, Colombia durante los años 2018 y 2019, mediante un estudio de campo longitudinal con nivel correlacional, partiendo de una población de 86 estudiantes de primer semestre de la Universidad de Santander (UDES) Campus Cúcuta, seleccionados aleatoriamente (consintiendo participar de manera voluntaria) con un rango de edades de 15-30 años. El estudio se realizó en dos fases, fase I (análisis al momento de la vinculación al estudio) y fase II (análisis 1 año después de la vinculación al estudio). En la fase I se determinó seroprevalencia al agente infeccioso y en la fase II el cambio del estado serológico (seroconversión) de los individuos inicialmente seronegativos. Como resultado, en la fase I se obtuvo la seroprevalencia frente al virus Dengue, la cual fue 75,6%, resaltando que la seropositividad fue mayor en la Facultad de Ciencias de la Salud obteniendo el 78,0%. En la segunda fase se evidenció la seroconversión en el 50,0% de la población evaluada, resaltando que el 35,7% pertenecía a programas académicos de la Facultad de Ciencias de la Salud.
- PublicaciónAcceso abiertoCo-circulation and simultaneous co-infection of dengue, chikungunya, and zika viruses in patients with febrile syndrome at the Colombian-Venezuelan border(2018-01-30) Carrillo Hernández, Marlen Yelitza; Gómez Rangel, Sergio-Yebrail; Ruiz Saenz, Julian; Jaimes Villamizar, Lucy; Martínez Gutiérrez, MarlenBackground: In Colombia, the dengue virus (DENV) has been endemic for decades, and with the recent entry of the chikungunya virus (CHIKV) (2014) and the Zika virus (ZIKV) (2015), health systems are overloaded because the diagnosis of these three diseases is based on clinical symptoms, and the three diseases share a symptomatology of febrile syndrome. Thus, the objective of this study was to use molecular methods to identify their co-circulation as well as the prevalence of co-infections, in a cohort of patients at the Colombian-Venezuelan border. Methods: A total of 157 serum samples from patients with febrile syndrome consistent with DENV were collected after informed consent and processed for the identification of DENV (conventional PCR and real-time PCR), CHIKV (conventional PCR), and ZIKV (real-time PCR). DENV-positive samples were serotyped, and some of those positive for DENV and CHIKV were sequenced. Results: Eighty-two patients were positive for one or more viruses: 33 (21.02%) for DENV, 47 (29.94%) for CHIKV, and 29 (18.47%) for ZIKV. The mean age range of the infected population was statistically higher in the patients infected with ZIKV (29.72 years) than in those infected with DENV or CHIKV (21.09 years). Both co-circulation and coinfection of these three viruses was found. The prevalence of DENV/CHIKV, DENV/ZIKV, and CHIKV/ZIKV co-infection was 7.64%, 6.37%, and 5.10%, with attack rates of 14.90, 12.42, and 9.93 cases per 100,000 inhabitants, respectively. Furthermore, three patients were found to be co-infected with all three viruses (prevalence of 1.91%), with an attack rate of 4.96 cases per 100,000 inhabitants. Conclusion: Our results demonstrate the simultaneous co-circulation of DENV, CHIKV, ZIKV and their co-infections at the Colombian-Venezuelan border. Moreover, it is necessary to improve the differential diagnosis in patients with acute febrile syndrome and to study the possible consequences of this epidemiological overview of the clinical outcomes of these diseases in endemic regions.
- PublicaciónAcceso abiertoDengue in Santander State, Colombia: fluctuations in the prevalence of virus serotypes are linked to dengue incidence and genetic diversity of the circulating viruses(2019-11-05) Carreño, María Fernanda; Jiménez-Silva, Cinthy Lorena; Rey-Caro, Luz Aida; Conde-Ocazionez, Sergio A.; Flechas-Alarcón, María Camila; Velandia, Sindi Alejandra; Ocazionez, Raquel Elvira; Neuro CienciasobjectiveTo investigate the link between fluctuations in the prevalence of dengue virus (DENV)serotypes and the number of dengue cases in the metropolitan area of Bucaramanga, Santander State,Colombia, in the 2007–2010 and 2014–2017 periods.methodViruses were isolated from febrile patient samples by direct application to C6/36-HT cellsand typed using monoclonal antibodies. We performed autocorrelation and cross-correlation analysesto determine whether fluctuations in the prevalence of DENV serotypes and dengue cases werecorrelated. Full envelope (E) gene sequences were employed to examine the genetic diversity ofserotypes circulating by using a phylogenetic approach.resultsAll four dengue virus serotypes were detected. DENV-1 was the dominant serotype in bothperiods followed by DENV-3 or DENV-2 depending on the period; DENV-4 was the least prevalentvirus in both periods. Cross-correlation analyses suggest a temporal relation between the fluctuationsin the prevalence of DENV serotypes, which were almost simultaneous (lag=0) or related to recentpast fluctuations (lag>1.0) in the number of dengue cases. Data suggest that a sustainedpredominance of DENV-1, an increase of the DENV-4 prevalence, and a switch from DENV-3 toDENV-2 could be linked to an outbreak. Circulating viruses were grouped into Genotype V, Asia/American III and II for DENV-1, -2, -3 and -4, respectively; intragenotypic diversity was detected.conclusionsThe present work highlights the need of comprehensive studies on dynamics of DENV inColombia to understand transmission of dengue and evaluate the effectiveness of a vaccination programme.