Examinando por Materia "Ligando de triazoles"
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- PublicaciónAcceso abiertoActividad antibacteriana y citotóxica in vitro de complejos metálicos con ligandos de triazoles(Bucaramanga : Universidad de Santander, 2020, 2020-01-20) Barajas Angarita, María Angélica; Sanabria Ayala, Martha Juliana; Roa Cordero, Martha Viviana; Leal Pinto, Sandra-MilenaThe emergence of antimicrobial resistance is currently a public health problem and one of the main challenges of modern medicine that has generated an increase in mortality and morbidity rates associated with infectious pathology. Consequently, WHO published a list of antibiotic-resistant priority pathogens to prioritize research and development of new drugs following the impact these bacteria generate on public health17. Objective. To evaluate the in vitro antimicrobial and cytotoxic activity of the chromium (III) and cobalt (II) metal complexes with triazole ligands in bacterial pathogens and mammalian cells. Methodology. The bioactivity of 6 chromium (III) and cobalt (II) complexes with triazole ligands, 2 inorganic sales and 3 free ligands was studied in reference strains of Staphylococcus aureus (ATTC 11632), Escherichia coli (ATCC10536) and Salmonella enterica serotype Typhimurium (ATCC14028), using the broth microdilution method (CLSI M07-A9). The cytotoxic activity on Vero Cells (CCL-81) was determined by the MTT colorimetric assay. Results: Moderate anti-S aureus activity was demonstrated of two of the three divalent cobalt complexes evaluated (MIC 500 μg mL-1). In general, trivalent chromium complexes and free ligands did not exhibit antibacterial activity (MIC> 2000 μg mL-1). None of the coordination compounds and free ligands studied were cytotoxic for mammalian cells (CC50> 130 μg mL-1). Conclusion: it is established that the chromium complexes and the triazole ligands evaluated do not show significant antibacterial activity. However, there was a moderate anti-S.aureus inhibitory effect produced by two of the trivalent cobalt complexes studied (ID: 4 (diacuadichloro [1,1 '- ((5-methyl-1,3-phenylene) bis ( methylene)) bis (1,2,4-triazole) -N, N '] cobalt (II)), ID: 7 (triacua dichloride [2,6-bis ((1,2,4-triazol-1- ) il) methyl) pyridine-N, N, N '] cobalt (II)), which can be studied in silica form to improve its biological activity. On the other hand, none of the compounds evaluated exhibited a cytotoxic effect against the previously evaluated vero cells.