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Risk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocols

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dc.contributor.authorMartínez Vega, Ruth Aralíspa
dc.contributor.authorReveiz, Ludovicspa
dc.contributor.authorHaby, Michelle M.spa
dc.contributor.authorPinzón Flores, Carlos E.spa
dc.contributor.authorElias, Vanessaspa
dc.contributor.authorSmith, Emmaspa
dc.contributor.authorPinart, Marionaspa
dc.contributor.authorBroutet, Nathaliespa
dc.contributor.authorBecerra Posada, Franciscospa
dc.contributor.authorAldighieri, Sylvainspa
dc.contributor.authorVan Kerkhove, Maria D.spa
dc.date.accessioned2019-06-25T16:32:20Zspa
dc.date.available2019-06-25T16:32:20Zspa
dc.date.issued2017-07-07spa
dc.description17 p.spa
dc.description.abstractGiven the severity and impact of the current Zika virus (ZIKV) outbreak in the Americas, numerous countries have rushed to develop research studies to assess ZIKV and its potential health consequences. In an effort to ensure that studies are comprehensive, both internally and externally valid, and with reliable results, the World Health Organization, the Pan American Health Organization, Institut Pasteur, the networks of Fiocruz, the Consortia for the Standardization of Influenza Seroepidemiology (CONSISE) and the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) have generated six standardized clinical and epidemiological research protocols and questionnaires to address key public health questions on ZIKV. Methods We conducted a systematic search of ongoing study protocols related to ZIKV research. We analyzed the content of protocols of 32 cohort studies and 13 case control studies for systematic bias that could produce erroneous results. Additionally we aimed to characterize the risks of bias and confounding in observational studies related to ZIKV and to propose ways to minimize them, including the use of six newly standardized research protocols. Results Observational studies of ZIKV face an array of challenges, including measurement of exposure and outcomes (microcephaly and Guillain-Barre´ Syndrome). Potential confounders need to be measured where known and controlled for in the analysis. Selection bias due tonon-random selection is a significant issue, particularly in the case-control design, and losses to follow-up is equally important for the cohort design. Conclusion Observational research seeking to answer key questions on the ZIKV should consider these restrictions and take precautions to minimize bias in an effort to provide reliable and valid results. Utilization of the standardized research protocols developed by the WHO, PAHO, Institut Pasteur, and CONSISE will harmonize the key methodological aspects of each study design to minimize bias at different stages of the study. Biases need to be considered by researchers implementing the standardized protocols as well as by users of observational epidemiological studies of ZIKV.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.1371/journal.pone.0180220eng
dc.identifier.issn1932-6203spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/3202spa
dc.language.isoengspa
dc.relation.ispartofPlos Oneeng
dc.rightsDerechos Reservados - Universidad de Santander, 2017spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0180220&type=printableeng
dc.subject.proposalZikaeng
dc.subject.proposalViruseng
dc.subject.proposalInfectioneng
dc.subject.proposalRiskeng
dc.titleRisk of bias and confounding of observational studies of Zika virus infection : A scoping review of research protocolseng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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