Enkephalins and ACTH in the mammalian nervous system

Duque Díaz, Ewing Rafael; Alvarez Ojeda, Olga; Coveñas, Rafael

Publicación:
Enkephalins and ACTH in the mammalian nervous system

dc.contributor.author	Duque Díaz, Ewing Rafael	spa
dc.contributor.author	Alvarez Ojeda, Olga	spa
dc.contributor.author	Coveñas, Rafael	spa
dc.date.accessioned	2019-09-19T15:49:39Z	spa
dc.date.available	2019-09-19T15:49:39Z	spa
dc.date.issued	2019-06-14	spa
dc.description	7 p.	spa
dc.description.abstract	The pentapeptides methionine-enkephalin and leucine-enkephalin belong to the opioid family of peptides, and the non-opiate peptide adrenocorticotropin hormone (ACTH) to the melanocortin peptide family. Enkephalins/ACTH are derived from pro-enkephalin, pro-dynorphin or pro-opiomelanocortin precursors and, via opioid and melanocortin receptors, are responsible for many biological activities. Enkephalins exhibit the highest affinity for the δ receptor, followed by the μ and κ receptors, whereas ACTH binds to the five subtypes of melanocortin receptor, and is the only member of the melanocortin family of peptides that binds to the melanocortin-receptor 2 (ACTH receptor). Enkephalins/ACTH and their receptors exhibit a widespread anatomical distribution. Enkephalins are involved in analgesia, angiogenesis, blood pressure, embryonic development, emotional behavior, feeding, hypoxia, limbic system modulation, neuroprotection, peristalsis, and wound repair; as well as in hepatoprotective, motor, neuroendocrine and respiratory mechanisms. ACTH plays a role in acetylcholine release, aggressive behavior, blood pressure, bone maintenance, hyperalgesia, feeding, fever, grooming, learning, lipolysis, memory, nerve injury repair, neuroprotection, sexual behavior, sleep, social behavior, tissue growth and stimulates the synthesis and secretion of glucocorticoids. Enkephalins/ACTH are also involved in many pathologies. Enkephalins are implicated in alcoholism, cancer, colitis, depression, heart failure, Huntington's disease, influenza A virus infection, ischemia, multiple sclerosis, and stress. ACTH plays a role in Addison's disease, alcoholism, cancer, Cushing's disease, dermatitis, encephalitis, epilepsy, Graves' disease, Guillain-Barré syndrome, multiple sclerosis, podocytopathies, and stress. In this review, we provide an updated description of the enkephalinergic and ACTH systems.	eng
dc.format.mimetype	application/pdf	spa
dc.identifier.doi	10.1016/bs.vh.2019.05.001	spa
dc.identifier.isbn	9780128188583	spa
dc.identifier.uri	https://repositorio.udes.edu.co/handle/001/3744	spa
dc.language.iso	eng	spa
dc.relation.ispartof	Opioid Hormones	eng
dc.relation.ispartofseries	Vitamins and Hormones;Volume 111, 2019, Chapter 7. Pages 147-193	eng
dc.rights	Derechos Reservados - Universidad de Santander, 2019	spa
dc.rights.accessrights	info:eu-repo/semantics/openAccess	spa
dc.rights.creativecommons	Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)	spa
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	spa
dc.source	https://www.sciencedirect.com/science/article/pii/S0083672919300378	eng
dc.subject.proposal	Adrenocorticotropin hormone	eng
dc.subject.proposal	Leucine-enkephalin	eng
dc.subject.proposal	Methionine-enkephalin	eng
dc.subject.proposal	Opioid	eng
dc.subject.proposal	Pro-enkephalin	eng
dc.title	Enkephalins and ACTH in the mammalian nervous system	eng
dc.type	Capítulo - Parte de Libro	spa
dc.type.coar	http://purl.org/coar/resource_type/c_3248	spa
dc.type.content	Text	spa
dc.type.driver	info:eu-repo/semantics/bookPart	spa
dc.type.redcol	https://purl.org/redcol/resource_type/CAP_LIB	spa
dc.type.version	info:eu-repo/semantics/publishedVersion	spa
dspace.entity.type	Publication
oaire.accessrights	http://purl.org/coar/access_right/c_abf2	spa
oaire.version	http://purl.org/coar/version/c_970fb48d4fbd8a85	spa