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Association of bedtime with mortality and major cardiovascular events: an analysis of 112,198 individuals from 21 countries in the PURE study

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dc.contributor.authorWang, Chuangshi
dc.contributor.authorHu, Bo
dc.contributor.authorRangarajan, Sumathy
dc.contributor.authorBangdiwala, Shrikant I.
dc.contributor.authorLear, Scott A.
dc.contributor.authorMohan, Viswanathan
dc.contributor.authorGupta, Rajeev
dc.contributor.authorAlhabib, Khalid F.
dc.contributor.authorSoman, Biju
dc.contributor.authorAbat, Marc Evans M.
dc.contributor.authorRosengren, Annika
dc.contributor.authorLanas, Fernando
dc.contributor.authorAvezum, Alvaro
dc.contributor.authorLopez-Jaramillo, Patricio
dc.contributor.authorDiaz, Rafael
dc.contributor.authorYusoff, Khalid
dc.contributor.authorIqbal, Romaina
dc.contributor.authorChifamba, Jephat
dc.contributor.authorYeates, Karen
dc.contributor.authorZatońska, Katarzyna
dc.contributor.authorKruger, Iolanthe M.
dc.contributor.authorBahonar, Ahmad
dc.contributor.authorYusufali, AfzalHussein
dc.contributor.authorLi, Wei
dc.contributor.authorYusuf, Salim
dc.contributor.authorThe Prospective Urban Rural Epidemiology (PURE) study investigators
dc.contributor.researchgroupMasiraspa
dc.date.accessioned2022-02-23T15:46:25Z
dc.date.available2022-02-23T15:46:25Z
dc.date.issued2021-04-05
dc.descriptionDigitalspa
dc.description.abstractObjectives This study aimed to examine the association of bedtime with mortality and major cardiovascular events. Methods Bedtime was recorded based on self-reported habitual time of going to bed in 112,198 participants from 21 countries in the Prospective Urban Rural Epidemiology (PURE) study. Participants were prospectively followed for 9.2 years. We examined the association between bedtime and the composite outcome of all-cause mortality, non-fatal myocardial infarction, stroke and heart failure. Participants with a usual bedtime earlier than 10PM were categorized as ‘earlier’ sleepers and those who reported a bedtime after midnight as ‘later’ sleepers. Cox frailty models were applied with random intercepts to account for the clustering within centers. Results A total of 5633 deaths and 5346 major cardiovascular events were reported. A U-shaped association was observed between bedtime and the composite outcome. Using those going to bed between 10PM and midnight as the reference group, after adjustment for age and sex, both earlier and later sleepers had a higher risk of the composite outcome (HR of 1.29 [1.22, 1.35] and 1.11 [1.03, 1.20], respectively). In the fully adjusted model where demographic factors, lifestyle behaviors (including total sleep duration) and history of diseases were included, results were greatly attenuated, but the estimates indicated modestly higher risks in both earlier (HR of 1.09 [1.03–1.16]) and later sleepers (HR of 1.10 [1.02–1.20]). Conclusion Early (10 PM or earlier) or late (Midnight or later) bedtimes may be an indicator or risk factor of adverse health outcomes.spa
dc.description.researchareaCiencias Médicas y de la Saludspa
dc.format.extent6 pspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.arkhttps://doi.org/10.1016/j.sleep.2021.01.057
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/6126
dc.language.isoengspa
dc.publisherElsevierspa
dc.publisher.placeCanadaspa
dc.relation.citationendpage272spa
dc.relation.citationstartpage265spa
dc.relation.citationvolume80spa
dc.relation.citesChuangshi Wang, Bo Hu, Sumathy Rangarajan, Shrikant I. Bangdiwala, Scott A. Lear, Viswanathan Mohan, Rajeev Gupta, Khalid F. Alhabib, Biju Soman, Marc Evans M. Abat, Annika Rosengren, Fernando Lanas, Alvaro Avezum, Patricio Lopez-Jaramillo, Rafael Diaz, Khalid Yusoff, Romaina Iqbal, Jephat Chifamba, Karen Yeates, Katarzyna Zatońska, Iolanthé M. Kruger, Ahmad Bahonar, Afzalhussein Yusufali, Wei Li, Salim Yusuf, Association of bedtime with mortality and major cardiovascular events: an analysis of 112,198 individuals from 21 countries in the PURE study, Sleep Medicine, Volume 80, 2021, Pages 265-272, ISSN 1389-9457, https://doi.org/10.1016/j.sleep.2021.01.057. (https://www.sciencedirect.com/science/article/pii/S1389945721000745)
dc.relation.citesChuangshi Wang, Bo Hu, Sumathy Rangarajan, Shrikant I. Bangdiwala, Sadi Gulec, Scott A. Lear, Viswanathan Mohan, Rajeev Gupta, Khalid F. Alhabib, Biju Soman, Marc Evans M. Abat, Annika Rosengren, Fernando Lanas, Alvaro Avezum, Patricio Lopez-Jaramillo, Rafael Diaz, Khalid Yusoff, Romaina Iqbal, Jephat Chifamba, Karen Yeates, Katarzyna Zatońska, Iolanthé M. Kruger, Ahmad Bahonar, Afzalhussein Yusufali, Wei Li, Salim Yusuf ‘Corrigendum to “Association of bedtime with mortality and major cardiovascular events: an analysis of 112,198 individuals from 21 countries in the PURE study” [Sleep Medicine 80 (2021) 265–272]’ Sleep Medicine, Available online 5 January 2022, Pages
dc.relation.indexedScopusspa
dc.relation.ispartofjournalSleep Medicinespa
dc.rights© 2021 The Authors, Published by Elsevier B.V.spa
dc.rights.accessrightsinfo:eu-repo/semantics/closedAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://www.sciencedirect.com/science/article/abs/pii/S1389945721000745#!spa
dc.subject.proposalBedtimeeng
dc.subject.proposalMortalityeng
dc.subject.proposalCardiovascular eventseng
dc.titleAssociation of bedtime with mortality and major cardiovascular events: an analysis of 112,198 individuals from 21 countries in the PURE studyspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceTodas las Audienciasspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_14cbspa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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