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Periodontal disease severity is related to high levels of C-reactive protein in pre-eclampsia

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dc.contributor.authorHerrera, Julián A.spa
dc.contributor.authorParra, Beatrizspa
dc.contributor.authorHerrera, Enriquespa
dc.contributor.authorBotero, Javier E.spa
dc.contributor.authorArce, Roger M.spa
dc.contributor.authorContreras, Adolfospa
dc.contributor.authorLopez-Jaramillo, Patriciospa
dc.date.accessioned2019-08-29T17:17:56Zspa
dc.date.available2019-08-29T17:17:56Zspa
dc.date.issued2007-07spa
dc.description6 p.spa
dc.description.abstractObjective Recent studies have shown that pre-eclamptic women present a high prevalence of periodontitis, suggesting that active periodontal disease may play a role in the pathogenesis of pre-eclampsia. The present study analysed the effect of periodontal disease in the concentrations of serum high-sensitivity C-reactive protein (hs-CRP), and its association with pre-eclampsia. Methods A case–control study was carried out in Cali-Colombia, comprised of 398 pregnant women (145 cases and 253 controls) who were believed to have periodontal disease, between 28 and 36 weeks of gestational age. Pre-eclampsia cases were defined as blood pressure >– 140/90 mmHg and proteinuria >– 0.3 g/24 h. Controls were pregnant women with normal blood pressure, without proteinuria, matched by maternal age, gestational age and body mass index. Sociodemographic data, obstetric risk factors, periodontal state, subgingival microbial composition and hs-CRP levels were determined in both groups. Results The case and control groups were comparable for sociodemographic characteristics. In women with pre-eclampsia and confirmed periodontal disease (n U 138), hs-CRP levels increased according to the severity of the disease (gingivitis median 4.14 mg/dl; mild periodontitis median 4.70 mg/dl; moderate/severe periodontitis median 8.8 mg/dl; P U 0.01). A similar tendency was observed in controls with periodontal disease (n U 251), but it did not reach statistical significance (gingivitis median 5.10 mg/dl; mild periodontitis median 5.12 mg/dl; moderate/severe periodontitis median 6.90 mg/dl; P U 0.07). A significant difference in hs-CRP levels was observed in pre-eclamptic women with moderate/severe periodontitis compared to controls (P U 0.01). Conclusion These findings suggest that chronic periodontitis may increase hs-CRP levels in pregnant women and lead to complications such as pre-eclampsia.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.1097/HJH.0b013e3281139ea9spa
dc.identifier.issn1473-5598spa
dc.identifier.issn0263-6352spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/3692spa
dc.language.isoengspa
dc.relation.ispartofJournal of Hypertensioneng
dc.relation.ispartofseriesJournal of Hypertension;Vol. 25 (7), pp. 1459-1464. 2007eng
dc.rightsDerechos Reservados - Journal of Hypertension, 2007spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://journals.lww.com/jhypertension/fulltext/2007/07000/Periodontal_disease_severity_is_related_to_high.23.aspx#pdf-linkeng
dc.subject.proposalBacterial infectioneng
dc.subject.proposalChronic periodontitiseng
dc.subject.proposalC-reactive proteineng
dc.subject.proposalPreeclampsiaeng
dc.titlePeriodontal disease severity is related to high levels of C-reactive protein in pre-eclampsiaeng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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