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Inflammation but not endothelial dysfunction is associated with the severity of coronary artery disease in dyslipidemic subjects

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dc.contributor.authorRueda Clausen, Christian F.spa
dc.contributor.authorLopez-Jaramillo, Patriciospa
dc.contributor.authorLuengas, Carlosspa
dc.contributor.authorOubiña, Maria del Pilarspa
dc.contributor.authorCachofeiro, Victoriaspa
dc.contributor.authorLahera, Vicentespa
dc.date.accessioned2019-07-08T12:30:18Zspa
dc.date.available2019-07-08T12:30:18Zspa
dc.date.issued2009-04spa
dc.description9 p.spa
dc.description.abstractEndothelial dysfunction and inflammation play a key role in the development of atherosclerosis. The present study evaluated endothelial function, inflammatory parameters, and carotid intima-media thickness (IMT) in dyslipidemic patients with or without coronary artery disease (CAD). Methods. Metabolic profile and inflammatory parameters were determined in dyslipidemic patients with (+CAD, n = 33) and without (−CAD, n = 69) symptomatic CAD. Endothelial function was evaluated by flow mediated dilatation (FMD) and plasma concentration of nitrites and nitrates. Carotid IMT was measured by ultrasound. Results. No significant differences were observed in anthropometric hemodynamic or metabolic parameters between the groups. After adjusting by age and medication usage, some inflammatory markers were significantly higher in +CAD; however. no significant differences in FMD or plasma levels of nitrites were observed. Conclusions. In subjects with dyslipidemia, the presence of CAD is associated with an elevation of certain inflammatory markers and carotid IMT but not with further endothelial dysfunction.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.1155/2009/469169spa
dc.identifier.isbn1466-1861spa
dc.identifier.issn0962-9351spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/3290spa
dc.language.isoengspa
dc.relation.ispartofMediators of Inflammationeng
dc.rightsDerechos Reservados - Mediators of Inflammation, 2009spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://www.hindawi.com/journals/mi/2009/469169/eng
dc.subject.proposalEndothelial Dysfunctioneng
dc.subject.proposalSeverity of Coronary Artery Diseaseeng
dc.subject.proposalDyslipidemic Subjectseng
dc.titleInflammation but not endothelial dysfunction is associated with the severity of coronary artery disease in dyslipidemic subjectseng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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