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A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR

dc.contributor.authorArndt, Claudia
dc.contributor.authorFeldmann, Anja
dc.contributor.authorKoristka, Stefanie
dc.contributor.authorSchäfer, Martin
dc.contributor.authorBergmann, Ralf
dc.contributor.authorMitwasi, Nicola
dc.contributor.authorBerndt, Nicole
dc.contributor.authorBachmann, Dominik
dc.contributor.authorKegler, Alexandra
dc.contributor.authorSchmitz, Marc
dc.contributor.authorPuentes-Cala, Edinson
dc.contributor.authorSoto, Javier-Andrés
dc.contributor.authorEhninger, Gerhard
dc.contributor.authorPietzsch, Jens
dc.contributor.authorLiolios, Christos
dc.contributor.authorWunderlich, Gerd
dc.contributor.authorKotzerke, Jörg
dc.contributor.authorKopka, Klaus
dc.contributor.authorBachmann, Michael
dc.contributor.editorTaylor & Francis Group
dc.date.accessioned2021-09-14T22:03:48Z
dc.date.available2021-09-14T22:03:48Z
dc.date.issued2019-09-07
dc.descriptionDigitalspa
dc.description.abstractChimeric antigen receptor (CAR) T cells have shown impressive therapeutic potential. Due to the lack of direct control mechanisms, therapy-related adverse reactions including cytokine release- and tumor lysis syndrome can even become life-threatening. In case of target antigen expression on non-malignant cells, CAR T cells can also attack healthy tissues. To overcome such side effects, we have established a modular CAR platform termed UniCAR: UniCAR T cells per se are inert as they recognize a peptide epitope (UniCAR epitope) that is not accessible on the surface of living cells. Bifunctional adapter molecules termed target modules (TM) can cross-link UniCAR T cells with target cells. In the absence of TMs, UniCAR T cells automatically turn off. Until now, all UniCAR TMs were constructed by fusion of the UniCAR epitope to an antibody domain. To open up the wide field of low-molecular-weight compounds for retargeting of UniCAR T cells to tumor cells, and to follow in parallel the progress of UniCAR T cell therapy by PET imaging we challenged the idea to convert a PET tracer into a UniCAR-TM. For proof of concept, we selected the clinically used PET tracer PSMA-11, which binds to the prostate-specific membrane antigen overexpressed in prostate carcinoma. Here we show that fusion of the UniCAR epitope to PSMA-11 results in a low-molecular-weight theranostic compound that can be used for both retargeting of UniCAR T cells to tumor cells, and for non-invasive PET imaging and thus represents a member of a novel class of theranostics.spa
dc.description.edition1 ed.spa
dc.format.extent1 pspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1080/2162402X.2019.1659095
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/5616
dc.language.isoengspa
dc.publisherTaylor & Francis Groupspa
dc.publisher.placeU.S.Aspa
dc.relation.citationendpage15spa
dc.relation.citationissue11spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume8spa
dc.relation.ispartofjournalONCOIMMUNOLOGYspa
dc.rights© 2019 The Author(s). Published with license by Taylor & Francis Group, LLCspa
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.sourcehttps://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1659095spa
dc.subject.proposalPSMA ligandeng
dc.subject.proposalUniCAReng
dc.subject.proposalProstate cancereng
dc.subject.proposalImmunotherapyeng
dc.subject.proposalPET imagingeng
dc.titleA theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCARspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceTodas las Audienciasspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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