Publicación: A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR
A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR
dc.contributor.author | Arndt, Claudia | |
dc.contributor.author | Feldmann, Anja | |
dc.contributor.author | Koristka, Stefanie | |
dc.contributor.author | Schäfer, Martin | |
dc.contributor.author | Bergmann, Ralf | |
dc.contributor.author | Mitwasi, Nicola | |
dc.contributor.author | Berndt, Nicole | |
dc.contributor.author | Bachmann, Dominik | |
dc.contributor.author | Kegler, Alexandra | |
dc.contributor.author | Schmitz, Marc | |
dc.contributor.author | Puentes-Cala, Edinson | |
dc.contributor.author | Soto, Javier-Andrés | |
dc.contributor.author | Ehninger, Gerhard | |
dc.contributor.author | Pietzsch, Jens | |
dc.contributor.author | Liolios, Christos | |
dc.contributor.author | Wunderlich, Gerd | |
dc.contributor.author | Kotzerke, Jörg | |
dc.contributor.author | Kopka, Klaus | |
dc.contributor.author | Bachmann, Michael | |
dc.contributor.editor | Taylor & Francis Group | |
dc.date.accessioned | 2021-09-14T22:03:48Z | |
dc.date.available | 2021-09-14T22:03:48Z | |
dc.date.issued | 2019-09-07 | |
dc.description | Digital | spa |
dc.description.abstract | Chimeric antigen receptor (CAR) T cells have shown impressive therapeutic potential. Due to the lack of direct control mechanisms, therapy-related adverse reactions including cytokine release- and tumor lysis syndrome can even become life-threatening. In case of target antigen expression on non-malignant cells, CAR T cells can also attack healthy tissues. To overcome such side effects, we have established a modular CAR platform termed UniCAR: UniCAR T cells per se are inert as they recognize a peptide epitope (UniCAR epitope) that is not accessible on the surface of living cells. Bifunctional adapter molecules termed target modules (TM) can cross-link UniCAR T cells with target cells. In the absence of TMs, UniCAR T cells automatically turn off. Until now, all UniCAR TMs were constructed by fusion of the UniCAR epitope to an antibody domain. To open up the wide field of low-molecular-weight compounds for retargeting of UniCAR T cells to tumor cells, and to follow in parallel the progress of UniCAR T cell therapy by PET imaging we challenged the idea to convert a PET tracer into a UniCAR-TM. For proof of concept, we selected the clinically used PET tracer PSMA-11, which binds to the prostate-specific membrane antigen overexpressed in prostate carcinoma. Here we show that fusion of the UniCAR epitope to PSMA-11 results in a low-molecular-weight theranostic compound that can be used for both retargeting of UniCAR T cells to tumor cells, and for non-invasive PET imaging and thus represents a member of a novel class of theranostics. | spa |
dc.description.edition | 1 ed. | spa |
dc.format.extent | 1 p | spa |
dc.format.mimetype | application/pdf | spa |
dc.identifier.doi | https://doi.org/10.1080/2162402X.2019.1659095 | |
dc.identifier.uri | https://repositorio.udes.edu.co/handle/001/5616 | |
dc.language.iso | eng | spa |
dc.publisher | Taylor & Francis Group | spa |
dc.publisher.place | U.S.A | spa |
dc.relation.citationendpage | 15 | spa |
dc.relation.citationissue | 11 | spa |
dc.relation.citationstartpage | 1 | spa |
dc.relation.citationvolume | 8 | spa |
dc.relation.ispartofjournal | ONCOIMMUNOLOGY | spa |
dc.rights | © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC | spa |
dc.rights.accessrights | info:eu-repo/semantics/restrictedAccess | spa |
dc.rights.creativecommons | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) | spa |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | spa |
dc.source | https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1659095 | spa |
dc.subject.proposal | PSMA ligand | eng |
dc.subject.proposal | UniCAR | eng |
dc.subject.proposal | Prostate cancer | eng |
dc.subject.proposal | Immunotherapy | eng |
dc.subject.proposal | PET imaging | eng |
dc.title | A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR | spa |
dc.type | Artículo de revista | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
dc.type.content | Text | spa |
dc.type.driver | info:eu-repo/semantics/article | spa |
dc.type.redcol | http://purl.org/redcol/resource_type/ART | spa |
dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
dcterms.audience | Todas las Audiencias | spa |
dspace.entity.type | Publication | |
oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
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