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Enkephalins and ACTH in the mammalian nervous system

dc.contributor.authorDuque-Diaz, Ewing Rafael
dc.contributor.authorAlvarez-Ojeda, Olga
dc.contributor.authorCoveñas, Rafael
dc.date.accessioned2022-05-09T23:11:07Z
dc.date.available2022-05-09T23:11:07Z
dc.date.issued2019-08-13
dc.descriptionDigitalspa
dc.description.abstractThe pentapeptides methionine-enkephalin and leucine-enkephalin belong to the opioid family of peptides, and the non-opiate peptide adrenocorticotropin hormone (ACTH) to the melanocortin peptide family. Enkephalins/ACTH are derived from pro-enkephalin, pro-dynorphin or pro-opiomelanocortin precursors and, via opioid and melanocortin receptors, are responsible for many biological activities. Enkephalins exhibit the highest affinity for the δ receptor, followed by the μ and κ receptors, whereas ACTH binds to the five subtypes of melanocortin receptor, and is the only member of the melanocortin family of peptides that binds to the melanocortin-receptor 2 (ACTH receptor). Enkephalins/ACTH and their receptors exhibit a widespread anatomical distribution. Enkephalins are involved in analgesia, angiogenesis, blood pressure, embryonic development, emotional behavior, feeding, hypoxia, limbic system modulation, neuroprotection, peristalsis, and wound repair; as well as in hepatoprotective, motor, neuroendocrine and respiratory mechanisms. ACTH plays a role in acetylcholine release, aggressive behavior, blood pressure, bone maintenance, hyperalgesia, feeding, fever, grooming, learning, lipolysis, memory, nerve injury repair, neuroprotection, sexual behavior, sleep, social behavior, tissue growth and stimulates the synthesis and secretion of glucocorticoids. Enkephalins/ACTH are also involved in many pathologies. Enkephalins are implicated in alcoholism, cancer, colitis, depression, heart failure, Huntington's disease, influenza A virus infection, ischemia, multiple sclerosis, and stress. ACTH plays a role in Addison's disease, alcoholism, cancer, Cushing's disease, dermatitis, encephalitis, epilepsy, Graves' disease, Guillain-Barré syndrome, multiple sclerosis, podocytopathies, and stress. In this review, we provide an updated description of the enkephalinergic and ACTH systems.eng
dc.format.extent47 pspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/bs.vh.2019.05.001
dc.identifier.eisbn10: 0128188588spa
dc.identifier.isbn9780128188583spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/6749
dc.language.isoengspa
dc.publisher.placeUSAspa
dc.relation.citationendpage193spa
dc.relation.citationstartpage147spa
dc.relation.citesEwing Duque-Díaz, Olga Alvarez-Ojeda, Rafael Coveñas, Chapter Seven - Enkephalins and ACTH in the mammalian nervous system, Editor(s): Gerald Litwack, Vitamins and Hormones, Academic Press, Volume 111, 2019, Pages 147-193, ISSN 0083-6729, ISBN 9780128188583, https://doi.org/10.1016/bs.vh.2019.05.001.
dc.relation.ispartofbookVitamins and Hormonesspa
dc.rightsCopyright © 2019 Elsevier Inc. All rights reserved.spa
dc.rights.accessrightsinfo:eu-repo/semantics/closedAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://www.sciencedirect.com/science/article/abs/pii/S0083672919300378spa
dc.subject.proposalAdrenocorticotropin hormoneeng
dc.subject.proposalLeucine-enkephalineng
dc.subject.proposalMethionine-enkephalineng
dc.subject.proposalOpioideng
dc.subject.proposalPro-enkephalineng
dc.titleEnkephalins and ACTH in the mammalian nervous systemspa
dc.typeCapítulo - Parte de Librospa
dc.type.coarhttp://purl.org/coar/resource_type/c_3248spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/bookPartspa
dc.type.redcolhttps://purl.org/redcol/resource_type/CAP_LIBspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceTodas las Audienciasspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_14cbspa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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