2026-05-01T19:45:10Zhttps://repositorio.udes.edu.co/server/oai/request

oai:repositorio.udes.edu.co:001/32642023-10-10T22:21:05Zcom_001_9433com_001_9402com_001_9395com_001_10col_001_9434

Bautista Amorocho, Henry Castellanos Domínguez, Yeny Zulay Rodríguez Villamizar, Laura Andrea Velandia Cruz, Sindi Alejandra Becerra Peña, Jeysson Andrey Farfán García, Ana Elvira 2019-07-05T14:44:15Z 2019-07-05T14:44:15Z 2014-12-02 1932-6203 https://repositorio.udes.edu.co/handle/001/3264 10.1371/journal.pone.0114272 14 p. Abstract Introduction: Chronic hepatitis B virus (HBV) infection is an increasing cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected individuals. HIV-positive patients are commonly co-infected with HBV due to shared routes of transmission. Objectives: Our aim was to determine the risk factors, prevalence, genotypes, and mutations of the Surface S gene of HBV, and occult hepatitis B infection (OBI) among patients infected with HIV in a northeastern Colombian city. Methods: A cross-sectional study was conducted with 275 HIV-positive patients attending an outpatient clinic in Bucaramanga, Colombia during 2009–2010. Blood samples were collected and screened for serological markers of HBV (anti-HBs, anti-HBc and HBsAg) through ELISA assay. Regardless of their serological profile, all samples were tested for the HBV S gene by nested-PCR and HBV genotypes were determined by phylogenetic inference. Clinical records were used to examine demographic, clinical, virological, immunological and antiretroviral therapy (ART) variables of HIV infection. Results: Participants were on average 37¡11 years old and 65.1% male. The prevalence of HIV-HBV coinfection was 12% (95%CI 8.4–16.4) of which 3.3% had active HBV infection and 8.7% OBI. The prevalence of HIV-HBV coinfection was associated with AIDS stage and ART treatment. Sequence analysis identifiedgenotype F, subgenotype F3 in 93.8% of patients and genotype A in 6.2% of patients. A C149R mutation, which may have resulted from failure in HBsAg detection, was found in one patient with OBI. Conclusions: The present study found a high prevalence of HIV-HBV coinfection with an incidence of OBI 2.6-fold higher compared to active HBV infection. These findings suggest including HBV DNA testing to detect OBI in addition to screening for HBV serological markers in HIV patients. application/pdf eng Plos One Derechos Reservados - Universidad de Santander, 2014 https://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114272&type=printable Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: High prevalence of occult hepatitis B and F3 subgenotype dominance Artículo de revista http://purl.org/coar/resource_type/c_6501 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Text http://purl.org/redcol/resource_type/ART Epidemiology Risk Factors Genotypes of HBV HIV-Infected Patients http://purl.org/coar/access_right/c_abf2 http://purl.org/coar/version/c_970fb48d4fbd8a85 Publicationopen.access