Examinando por Autor "Clausen, Christian"

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  • Publicación
    Acceso abierto
    Polypill. An affordable strategy for cardiovascular disease prevention in low–medium-income countries
    (2018-01-15) Lopez-Jaramillo, Patricio; González Gómez, Silvia; Zarate Bernal, Diego; Serrano, Andrés; Atuesta, Leonor; Clausen, Christian; Castro Valencia, Claudia; Camacho López, Paul Anthony; Otero, Johanna
    The simplification of fixed dose medications by using a single ‘polypill’ is an attractive strategy to improve adherence to medications which has shown benefit to cardiovascular risk factor control and cardiovascular disease prevention or delay in the progression of these diseases. We review the evidence obtained from a series of clinical trials demonstrating an improvement in adherence to the polypill compared to the use of each compound separately, and found similar or better control of the classical cardiovascular risk factors and a similar safety profile. These results suggest that the use of the polypill could have a beneficial impact in cardiovascular morbidity and mortality. Furthermore, the polypill has the potential to improve cost effectiveness and is simple to use. However, before recommending the implementation of the polypill in programs aimed at primary and secondary cardiovascular prevention, we are awaiting the results of several current clinical trials aimed at measuring the impact on the frequency of major cardiovascular outcomes, particularly in low–medium-income countries.
  • Publicación
    Acceso abierto
    The spectrum of the dyslipidemia in Colombia. The PURE study
    (2019) Camacho López, Paul Anthony; Otero, Johanna; Pérez, Maritza; Arcos, Edgar; García, Henry; Narvaez, Claudia; Molina, Dora I.; Sánchez Vallejo, Gregorio; Durán Parra, Myriam; Cure, Carlos; Sotomayor Rubio, Aristides; Rico, Alvaro; Cotes, Fresia; Rangarajan, Sumathy; Yusuf, Salim; Cohen, Daniel Dylan; González Gómez, Silvia; Clausen, Christian; Lopez-Jaramillo, Patricio
    Background Dyslipidemia is a major risk factor for cardiovascular diseases (CVD). Worldwide, a third of ischemic heart disease is due to abnormal cholesterol levels and it is the most common cause of cardiovascular deaths in Colombia. In Colombia, no representative, large-scale study has assessed the prevalence of dyslipidemia. The aim of the present analysis was to identify the magnitude of the problem in Colombia, a middle-income-country with large regional, geographic, and socio-economical differences. Material and methods The sample comprised 6628 individuals aged 35 to 70 years (mean age 50.7 years, 64.1% women) residing in the four Colombian regions. Results The overall prevalence of dyslipidemia was 87.7% and was substantially higher among participants older than 50 years, male, rural residents, and those with a lower level of education (66.8%), and with a lower income (66.4%). High non HDL-c was the most common abnormality (75.3%). The values of total cholesterol and non-HDL-cholesterol were higher in areas with the lowest health needs index than in the areas with intermediate and highest health need index, the isolated HDL-c value was much lower. Conclusion Colombia has a high prevalence of abnormalities of the lipid profile. The causes of the high rates of dyslipidemia were not well define in this study, but were more common in rural and poorer regions and among those with lower socio-economical status. Strategies to tackle the adverse lipid profile to reduce CVD are needed in Colombia, particularly in rural areas and among the areas with the higher health need index.