Examinando por Autor "Prada, Diddier G."

Mostrando 1 - 6 de 6
  • Publicación
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    Chemosensory disturbances-associated nanocholinergic dysfunction : The case of, not only, myasthenia gravis
    (2015-09-01) Leon Sarmiento, Fidias E.; Leon-Ariza, Juan S.; Prada, Diddier G.; Leon-Ariza, Daniel S.
  • Publicación
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    Corrigendum to "A new neurometric dissection of the area-under-curve-associated jiggle of the motor evoked potential induced by transcranial magnetic stimulation"
    (2015-12-01) Leon-Sarmiento, Fidias E.; Rizzo Sierra, Carlos V.; Leon-Ariza, Juan S.; Leon-Ariza, Daniel S.; Sobota, Rosanna; Prada, Diddier G.
  • Publicación
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    Key Aspects in Foramen Magnum Meningiomas: From Old Neuroanatomical Conceptions to Current Far Lateral Neurosurgical Intervention
    (2017-10) Leon-Ariza, Daniel S.; Campero, Alvaro; Romero Chaparro, Rubby J.; Prada, Diddier G.; Vargas Grau, Gabriel; Rhoton Jr., Albert L.
    Foramen magnum meningiomas represent a challenge for neurosurgeons. These tumors require careful surgical manipulation as they are often located in proximity to critical neurovascular structures and the cranial nerves. The far lateral approach is considered the safest neurosurgical approach for excising foramen magnum lesions. It facilitates the access to the anterior foramen magnum and reduces the retraction of vital structures. We describe key historical, epidemiological, genetic, epigenetic, clinical, and neurosurgical aspects of foramen magnum meningiomas. We emphasize the far lateral approach for lesions arising in the foramen magnum, as well as the most appropriate patient positioning for such approach. Caring for these aspects will be rewarded with the best perioperative neurosurgical outcomes.
  • Publicación
    Acceso abierto
    A new neurometric dissection of the area-under-curve-associated jiggle of the motor evoked potential induced by transcranial magnetic stimulation
    (2015-02-14) Leon-Sarmiento, Fidias E.; Rizzo Sierra, Carlos V.; Leon-Ariza, Juan S.; Leon-Ariza, Daniel S.; Sobota, Rosanna; Prada, Diddier G.
    Objective The jiggle of the motor evoked potential (MEP) induced by transcranial magnetic stimulation (TMS) depends on a number of factors including the assessment of this stochastic signal by the method known as area under curve (AUC). We aim to ascertain the MEP findings assessed by the AUC method obtained from individuals affected by lesions at different levels of the neuroaxis. Methods We systematically search and critically appraise the scientific reports publishing on the MEP obtained from individuals with hypo- or hyperkinetic disorders of the neural system, and dissect the neurophysical assessment of the obtained data. To accomplish this, we used the instruments named to as U-Pen Instrument for Neurometric Evaluation Uncommonly and Rarely Obtained from NeuroSignals 1.0 (UPINEURON 1.0), and the Quality of Assessment Statistics Index (QuASI). Results The MEP differences found by the classical peak-to-peak method decreased or disappeared when the AUC was used. The opposite was also true (Kappa = < 0.00). The internal consistency of the UPINEURON was 0.88. The mean of the UPINEURON 1.0 indicator was 34.8 (range = 16–50), and the mean of the QuASI scores was 56.5 (range 30–80). Spearman correlation between UPINEURON 1.0 and QuASI was 0.513. Conclusions The MEP jiggle found in individuals with disordered neural function is not a “minor” factor; it is beyond the underlying neural condition, sample size, type of coils, and number of trials, among other variables. The use of the novel indicators introduced in this investigation will help to improve the analysis of the AUC of neural signals. They may also lead to the reconsideration of current practices.
  • Publicación
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    Sensory aspects in myasthenia gravis : A translational approach
    (2016-09-15) Leon-Sarmiento, Fidias E.; Leon-Ariza, Juan S.; Prada, Diddier G.; Leon-Ariza, Daniel S.; Rizzo Sierra, Carlos V.
    Myasthenia gravis is a paradigmatic muscle disorder characterized by abnormal fatigue and muscle weakness that worsens with activities and improves with rest. Clinical and research studies done on nicotinic acetylcholine receptors have advanced our knowledge of the muscle involvement in myasthenia. Current views still state that sensory deficits are not “features of myasthenia gravis”. This article discusses the gap that exists on sensory neural transmission in myasthenia that has remained after > 300 years of research in this neurological disorder. We outline the neurobiological characteristics of sensory and motor synapses, reinterpret the nanocholinergic commonalities that exist in both sensory and motor pathways, discuss the clinical findings on altered sensory pathways in myasthenia, and propose a novel way to score anomalies resulting from multineuronal inability associated sensory troubles due to eugenic nanocholinergic instability and autoimmunity. This medicine-based evidence could serve as a template to further identify novel targets for studying new medications that may offer a better therapeutic benefit in both sensory and motor dysfunction for patients. Importantly, this review may help to re-orient current practices in myasthenia.
  • Publicación
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    The Three Nociceptive Responses of the Orbicularis Oculi Reflex in Alzheimer’s Disease : State of the Evidence and Meta-analysis
    (2019-01) Leon Ariza, Daniel S.; Leon Ariza, Juan S.; Prada, Diddier G.; Castillo, Camilo; Leon Sarmiento, Fidias E.
    There is an emerging belief that electrically elicited blink reflexes (BR) may distinguish Alzheimer’s disease (AD) from other disorders characterized by memory dysfunction. To qualitatively and quantitatively distinguish the effects that electrical stimulation has over the blink reflex (eBR) recorded from patients with AD and healthy controls (HCs), we did a systematic review of the literature, and conducted a meta-analysis. Following our selected criteria, 94 AD patients and 97 HCs were identified from articles published in English between 1950 and 2017. Although the 3 responses (R1, R2 and R3) of the eBR were studied in a number of patients, only the R2 response was quantified in all studies. Thresholds and stimulation intensities parameters were found to be used in a miscellaneous form, and the majority of times, such parameters deviated from validated guidelines. The stimulation frequencies used to elicit the BR responses ranged between 0.14 and 0.2 Hz. These frequencies favored HCs compared with AD patients (odds ratio = 1.08; 95% CI = 0.30-1.85), I2 = 0% [P = .99]; Q = 271.89 [df = 7, P < .000]). Egger’s regression test suggested publication bias (intercept = 32.38; 95% CI = −8.98 to −3.2; P = .001). Our results unveiled key shortcomings in the data reported; such shortcomings need to be corrected in future AD research looking for obtaining more reliable and reproducible eBR studies; otherwise, interventions may be misleading.