Examinando por Autor "Raju, Sharat"

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  • Publicación
    Acceso abierto
    Neuroradiology and histopathology in two cases of adult medulloblastoma
    (2014) Romero Rojas, Alfredo E.; Diaz Perez, Julio A.; Raju, Sharat; Lozano Castillo, Alfonso
    Medulloblastoma (MB) is the most common central nervous system neoplasm in children and only rarely presents in the adult population. Recent molecular biology findings have characterized MB as a heterogeneous neoplasm distinguished by well-defined tumour subsets each with specific histologic and molecular features. Available immunohistochemical stains can now be used to differentiate the distinct molecular types of MB. This report analyzed the histopathologic and neuroradiologic features of two new cases of adult MB. Imaging studies in these patients revealed the morphological appearance of high-grade, well-circumscribed heterogeneous tumours with necrosis, located laterally within the posterior cranial fossa. Histopathology of resected samples demonstrated high-grade tumours (WHO grade IV) containing sheets of undifferentiated neural cells with high mitotic activity and evidence of necrosis. The histopathologic and molecular characteristics of these cases of MB are reviewed for potential applications in new molecular methods of imaging.
  • Publicación
    Acceso abierto
    Primary diffuse large B-cell lymphoma associated with chronic osteomyelitis of the knee
    (2014-12) Romero Rojas, Alfredo E.; Diaz Perez, Julio A.; Raju, Sharat; Messa Botero, Oscar; Prieto Bletan, Andres; Criollo Palacios, Felipe
    Diffuse large B-cell lymphoma (DLBCL) associated with chronic inflammation is a recently adopted category of DLBCL, which describes an aggressive B-cell lymphoma raised in the setting of non-immune chronic inflammation. Primary presentation of this subtype of DLBCL in bone is extremely rare. Here, we present the case of a 27 year old woman with DLBCL of the right distal femur, identified after a three-year history of chronic osteomyelitis. In this report, we describe the clinical and histopathologic features of this unusual presentation of DLBCL and discuss aspects relevant to diagnosis and treatment of this entity.