Examinando por Autor "Ramírez Quijano, Angelíca María"

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  • Publicación
    Restringido
    Seroprevalencia de Toxoplasma Gondii en donantes del Banco de sangre de la E.S.E HOSPITAL UNIVERSITARIO ERAZMO MEOZ, CUCUTA, COLOMBIA, año 2016.
    (Cúcuta: Universidad de Santander, 2017, 2017-06-20) Rangel Arias, Diana Marcela; Ramírez Quijano, Angelíca María; Contreras Rangel, Jael.
    Toxoplasmosis, a zoonosis considered endemic throughout the world due to its wide geographic distribution; Affects humans from asymptomatic to severe disease and death according to the individual's immunity. It is produced by Toxoplasma gondii, an obligate intracellular protozoal whose transmission mechanisms include classic pathways such as the intake of raw, poorly cooked, water or food contaminated with the parasite and transplacental transmission. It also includes alternate pathways such as organ transplantation and blood transfusion; A transcendental fact when it is considered that the spread of infectious agents and their impact on the public health of populations reaches a high point when there is a feasibility that donors of blood with asymptomatic infection can contribute to the dissemination of these entities in the population. In toxoplasmosis, more than 80% of infected patients can not present clinical manifestations and in Colombia, the mandatory tests in Blood Banks do not include any screening for this agent. The knowledge of epidemiological measures such as the prevalence and the incidence of events of interest within a specific population, allows to select better intervention measures and to monitor their effectiveness in a contextualized way.
  • Publicación
    Acceso abierto
    Seroprevalencia y detección molecular de Toxoplasma gondii en donantes de un banco de sangre de Cúcuta, Colombia
    (Biomédica: Revista del Instituto Nacional de Salud, 2019-08-01) Ramírez Quijano, Angelíca María; Ríos, Yesmit Karina; Galvis Serrano, Nestor Fabián; Rangel Arias, Diana Marcela; Araque María Alejandra; Cabarique, Darlis Mayerlis; Entrena, Elsie; Mariño, Nidia Victoria; Murillo, Mateo; Gómez-Marín, Jorge Enrique
    Introduction:Toxoplasma gondii infection manifests differently in humans according to their immunity ranging from asymptomatic profiles to severe disease. There are multiple transmission mechanisms including blood transfusions, but little is known about the frequency of T. gondii infection in Colombia’s blood banks. Objective: To determine the prevalence of T. gondii infection in blood donors of a blood bank in the city of Cúcuta by serological and molecular diagnostic techniques.Materials and methods: We identified IgG and IgM antibodies against T. gondii by immunoassay in serum from 348 donors. The frequency of T. gondii DNA was determined by polymerase chain reaction (PCR) in whole blood from seropositive donors and relevant variables were analyzed based on the information obtained from surveys during blood donor selection. Results: Out of the 348 enrolled donors, 134 (38.5%) showed IgG antibodies against T. gondii; two of them (0.6%) had both IgG and IgM, and in two of them (1.5%), parasite DNA was detected in blood samples. A bivariate analysis indicated an association between seropositivity to T. gondii and being over 26 years of age (p=0.020).Conclusions: The prevalence of T. gondii infection found in the blood donors of this study suggests a significant exposure to the infectious agent that becomes relevant when parasitemia is detected