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Dysfunctional chemosensation in myasthenia gravis : A systematic review

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dc.contributor.authorLeon Sarmiento, Fidias E.spa
dc.contributor.authorLeon Ariza, Daniel S.spa
dc.contributor.authorDoty, Richard L.spa
dc.date.accessioned2019-08-16T17:16:03Zspa
dc.date.available2019-08-16T17:16:03Zspa
dc.date.issued2013-09spa
dc.description6 p.spa
dc.description.abstractMyasthenia gravis has traditionally been viewed as a disorder that solely affects the neuromuscular junction within the peripheral nervous system. However, there is now evidence that the cholinergic dysfunction of this disorder may be more widespread than previously believed. This article provides a systematic review of the studies that examined smell and taste function in myasthenia gravis. Methods: We analyzed studies that reported chemosensory function alterations in patients with myasthenia gravis. PubMed, MEDLINE, Web of Science, EMBASE, and SciELO, searched to identify articles published from January 1950 through December 2012, were supplemented by relevant articles. The following information was identified from each article: the number of patients, number of controls (if any), clinical stage of patients, neurological involvement, serological state, taste or smell involvement, chemosensory test used, and country of publication. Results: Ten studies reporting smell and taste function and dysfunction in patients with myasthenia gravis were identified, most of which were case reports commenting on apparent abnormalities in the taste system. The sole empirical study that investigated taste function, however, was negative, suggesting that some reports of taste loss may reflect olfactory loss. One study clearly documented olfactory dysfunction in patients with myasthenia gravis, dysfunction most likely attributable to altered central nervous system cholinergic function. Conclusions: Chemosensory dysfunction has been reported in a number of patients with myasthenia gravis. Given the close association between complaints of taste dysfunction and loss of flavor sensations secondary to olfactory system damage, quantitative testing should be used to accurately assess the nature and degree of the dysfunction present in this debilitating disorder.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.1097/CND.0b013e31829e22baspa
dc.identifier.issn1537-1611spa
dc.identifier.issn1522-0443spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/3593spa
dc.language.isospaspa
dc.relation.ispartofJournal of Clinical Neuromuscular Diseaseeng
dc.relation.ispartofseriesJournal of Clinical Neuromuscular Disease;Vol. 15 (1), pp. 1-6. 2013eng
dc.rightsDerechos Reservados - Universidad de Santander, 2013spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://journals.lww.com/jcnmd/fulltext/2013/09000/Dysfunctional_Chemosensation_in_Myasthenia_Gravis_.1.aspx#pdf-linkeng
dc.subject.proposalMyasthenia graviseng
dc.subject.proposalSmelleng
dc.subject.proposalTasteeng
dc.subject.proposalParkinson diseaseeng
dc.subject.proposalAlzheimer diseaseeng
dc.titleDysfunctional chemosensation in myasthenia gravis : A systematic revieweng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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