Publicación:
Urinary Sodium and Potassium, and Risk of Ischemic and Hemorrhagic Stroke (INTERSTROKE). A Case-Control Study

Página de artículo simple
dc.contributor.authorJudge, Conor
dc.contributor.authorO’Donnell, Martin J.
dc.contributor.authorHankey, Graeme J.
dc.contributor.authorRangarajan, Sumathy
dc.contributor.authorLim Chin, Siu
dc.contributor.authorRao-Melacini, Purnima
dc.contributor.authorFerguson, John
dc.contributor.authorSmyth, Andrew
dc.contributor.authorXavier, Denis
dc.contributor.authorLisheng, Liu
dc.contributor.authorZhang, Hongye
dc.contributor.authorLopez-Jaramillo, Patricio
dc.contributor.authorDamasceno, Albertino
dc.contributor.authorLanghorne, Peter
dc.contributor.authorRosengren, Annika
dc.contributor.authorDans, Antonio
dc.contributor.authorElsayed, Ahmed
dc.contributor.authorAvezum, Alvaro
dc.contributor.authorMondo, Charles
dc.contributor.authorRyglewicz, Danuta
dc.contributor.authorCzlonkowska, Anna
dc.contributor.authorPogosova, Nana
dc.contributor.authorWeimar, Christian
dc.contributor.authorDiaz, Rafael
dc.contributor.authorYusoff, Khalid
dc.contributor.authorYusufali, Afzalhussein
dc.contributor.authorOguz, Aytekin
dc.contributor.authorWang, Xingyu
dc.contributor.authorLanas, Fernando
dc.contributor.authorOgah, Okechukwu S.
dc.contributor.authorOgunniyi, Adesola
dc.contributor.authorIversen, Helle K.
dc.contributor.authorMalaga, German
dc.contributor.authorRumboldt, Zvonko
dc.contributor.authorOveisgharan, Shahram
dc.contributor.authorHussain, Fawaz Al
dc.contributor.authorYusuf, Salim
dc.contributor.authorINTERSTROKE investigators
dc.contributor.researchgroupMasiraspa
dc.date.accessioned2022-02-18T16:38:30Z
dc.date.available2022-02-18T16:38:30Z
dc.date.issued2021-04-01
dc.descriptionDigitalspa
dc.description.abstractBACKGROUND Although low sodium intake (<2 g/day) and high potassium intake (>3.5 g/day) are proposed as public health interventions to reduce stroke risk, there is uncertainty about the benefit and feasibility of this combined recommendation on prevention of stroke. METHODS We obtained random urine samples from 9,275 cases of acute first stroke and 9,726 matched controls from 27 countries and estimated the 24-hour sodium and potassium excretion, a surrogate for intake, using the Tanaka formula. Using multivariable conditional logistic regression, we determined the associations of estimated 24-hour urinary sodium and potassium excretion with stroke and its subtypes. RESULTS Compared with an estimated urinary sodium excretion of 2.8–3.5 g/day (reference), higher (>4.26 g/day) (odds ratio [OR] 1.81; 95% confidence interval [CI], 1.65–2.00) and lower (<2.8 g/day) sodium excretion (OR 1.39; 95% CI, 1.26–1.53) were significantly associated with increased risk of stroke. The stroke risk associated with the highest quartile of sodium intake (sodium excretion >4.26 g/day) was significantly greater (P < 0.001) for intracerebral hemorrhage (ICH) (OR 2.38; 95% CI, 1.93–2.92) than for ischemic stroke (OR 1.67; 95% CI, 1.50–1.87). Urinary potassium was inversely and linearly associated with risk of stroke, and stronger for ischemic stroke than ICH (P = 0.026). In an analysis of combined sodium and potassium excretion, the combination of high potassium intake (>1.58 g/day) and moderate sodium intake (2.8–3.5 g/day) was associated with the lowest risk of stroke. CONCLUSIONS The association of sodium intake and stroke is J-shaped, with high sodium intake a stronger risk factor for ICH than ischemic stroke. Our data suggest that moderate sodium intake—rather than low sodium intake—combined with high potassium intake may be associated with the lowest risk of stroke and expected to be a more feasible combined dietary target.spa
dc.description.researchareaCiencias Médicas y de la Saludspa
dc.format.extent12 pspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1093/ajh/hpaa176
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/6052
dc.language.isoengspa
dc.publisherOxford Academicspa
dc.publisher.placeReino Unidospa
dc.relation.citationendpage425spa
dc.relation.citationissue4spa
dc.relation.citationstartpage414spa
dc.relation.citationvolume34spa
dc.relation.citesConor Judge, Martin J O’Donnell, Graeme J Hankey, Sumathy Rangarajan, Siu Lim Chin, Purnima Rao-Melacini, John Ferguson, Andrew Smyth, Denis Xavier, Liu Lisheng, Hongye Zhang, Patricio Lopez-Jaramillo, Albertino Damasceno, Peter Langhorne, Annika Rosengren, Antonio L Dans, Ahmed Elsayed, Alvaro Avezum, Charles Mondo, Danuta Ryglewicz, Anna Czlonkowska, Nana Pogosova, Christian Weimar, Rafael Diaz, Khalid Yusoff, Afzalhussein Yusufali, Aytekin Oguz, Xingyu Wang, Fernando Lanas, Okechukwu S Ogah, Adesola Ogunniyi, Helle K Iversen, German Malaga, Zvonko Rumboldt, Shahram Oveisgharan, Fawaz Al Hussain, Salim Yusuf, on behalf of the INTERSTROKE investigators, Urinary Sodium and Potassium, and Risk of Ischemic and Hemorrhagic Stroke (INTERSTROKE): A Case–Control Study, American Journal of Hypertension, Volume 34, Issue 4, April 2021, Pages 414–425, https://doi.org/10.1093/ajh/hpaa176
dc.relation.indexedScopusspa
dc.relation.ispartofjournalAmerican Journal of Hypertensionspa
dc.rightsCopyright © 2021, Oxford University Pressspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://academic.oup.com/ajh/article/34/4/414/5983728spa
dc.subject.proposalBlood pressureeng
dc.subject.proposalHypertensioneng
dc.subject.proposalIntracerebral hemorrhageeng
dc.subject.proposalIschemic strokeeng
dc.subject.proposalPotassiumeng
dc.subject.proposalSodiumeng
dc.subject.proposalStrokeeng
dc.titleUrinary Sodium and Potassium, and Risk of Ischemic and Hemorrhagic Stroke (INTERSTROKE). A Case-Control Studyspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceTodas las Audienciasspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
Archivos
Paquete original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Urinary Sodium and Potassium, and Risk of Ischemic and Hemorrhagic Stroke (INTERSTROKE). A Case-Control Study.pdf
Tamaño:
226.52 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Paquete de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
59 B
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
AGBBA. Artículos de Investigación