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Repetitive transcranial magnetic stimulation for phantom limb pain in land mine victims : A double-blinded, randomized, sham-controlled trial

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dc.contributor.authorMalavera Angarita, Mayra Alejandraspa
dc.contributor.authorSilva Sieger, Federico Arturospa
dc.contributor.authorFregni, Felipespa
dc.contributor.authorCarrillo Villa, Sandraspa
dc.contributor.authorGarcía, Ronald G.spa
dc.date.accessioned2019-07-30T17:43:11Zspa
dc.date.available2019-07-30T17:43:11Zspa
dc.date.issued2016-08spa
dc.description8 p.spa
dc.description.abstractWe evaluated the effects of repetitive transcranial magnetic stimulation (rTMS) in the treatment of phantom limb pain (PLP) in land mine victims. Fifty-four patients with PLP were enrolled in a randomized, double-blinded, placebo-controlled, parallel group single-center trial. The intervention consisted of real or sham rTMS of M1 contralateral to the amputated leg. rTMS was given in series of 20 trains of 6-second duration (54-second intertrain, intensity 90% of motor threshold) at a stimulation rate of 10 Hz (1,200 pulses), 20 minutes per day, during 10 days. For the control group, a sham coil was used. The administration of active rTMS induced a significantly greater reduction in pain intensity (visual analogue scale scores) 15 days after treatment compared with sham stimulation (−53.38 ± 53.12% vs −22.93 ± 57.16%; mean between-group difference = 30.44%, 95% confidence interval, .30–60.58; P = .03). This effect was not significant 30 days after treatment. In addition, 19 subjects (70.3%) attained a clinically significant pain reduction (>30%) in the active group compared with 11 in the sham group (40.7%) 15 days after treatment (P = .03). The administration of 10 Hz rTMS on the contralateral primary motor cortex for 2 weeks in traumatic amputees with PLP induced significant clinical improvement in pain. Perspective High-frequency rTMS on the contralateral primary motor cortex of traumatic amputees induced a clinically significant pain reduction up to 15 days after treatment without any major secondary effect. These results indicate that rTMS is a safe and effective therapy in patients with PLP caused by land mine explosions.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.1016/j.jpain.2016.05.003spa
dc.identifier.issn1526-5900spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/3496spa
dc.language.isoengspa
dc.relation.ispartofThe Journal of Paineng
dc.rightsDerechos Reservados - Universidad de Santander, 2016spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://www.sciencedirect.com/science/article/abs/pii/S1526590016300645?via%3Dihubeng
dc.subject.proposalPhantom limb paineng
dc.subject.proposalland mine victimseng
dc.subject.proposalrTMSeng
dc.subject.proposalNeuropathic paineng
dc.subject.proposalNoninvasive brain stimulationeng
dc.titleRepetitive transcranial magnetic stimulation for phantom limb pain in land mine victims : A double-blinded, randomized, sham-controlled trialeng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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