Is myopia another clinical manifestation of insulin resistance?

Galvis, Virgilio; Lopez-Jaramillo, Patricio; Tello, Alejandro; Castellanos Castellanos, Yuly Andrea; Camacho López, Paul Anthony; Cohen, Daniel Dylan; Gómez Arbeláez, Diego; Merayo Lloves, Jesús

Publicación:
Is myopia another clinical manifestation of insulin resistance?

dc.contributor.author	Galvis, Virgilio	spa
dc.contributor.author	Lopez-Jaramillo, Patricio	spa
dc.contributor.author	Tello, Alejandro	spa
dc.contributor.author	Castellanos Castellanos, Yuly Andrea	spa
dc.contributor.author	Camacho López, Paul Anthony	spa
dc.contributor.author	Cohen, Daniel Dylan	spa
dc.contributor.author	Gómez Arbeláez, Diego	spa
dc.contributor.author	Merayo Lloves, Jesús	spa
dc.date.accessioned	2019-07-26T12:43:40Z	spa
dc.date.available	2019-07-26T12:43:40Z	spa
dc.date.issued	2016-02	spa
dc.description	9 p.	spa
dc.description.abstract	Myopia is a multifactorial visual refraction disease, in which the light rays from distant objects are focused in front of retina, causing blurry vision. Myopic eyes are characterized by an increased corneal curvature and/or ocular axial length. The prevalence of myopia has increased in recent decades, a trend that cannot be attributed exclusively to genetic factors. Low and middle income countries have a higher burden of refractive error, which we propose could be a consequence of a shorter exposure time to a westernized lifestyle, a phenomenon that may also explain the rapid increase in cardiometabolic diseases, such as diabetes, among those populations. We suggest that interactions between genetic, epigenetic and a rapidly changing environment are also involved in myopia onset and progression. Furthermore, we discuss several possible mechanisms by which insulin resistance may promote abnormal ocular growth and myopia to support the hypothesis that insulin resistance and hyperinsulinemia are involved in its pathogenesis, providing a link between trends in myopia and those of cardiometabolic diseases. There is evidence that insulin have direct ocular growth promoting effects as well an indirect effect via the induction of insulin-like growth factors leading to decreases insulin-like growth factor-binding protein, also implicated in ocular growth.	eng
dc.format.mimetype	application/pdf	spa
dc.identifier.doi	10.1016/j.mehy.2016.02.006	spa
dc.identifier.issn	0306-9877	spa
dc.identifier.uri	https://repositorio.udes.edu.co/handle/001/3461	spa
dc.language.iso	eng	spa
dc.relation.ispartof	Medical Hypotheses	eng
dc.rights	Derechos Reservados - Universidad de Santander, 2016	spa
dc.rights.accessrights	info:eu-repo/semantics/openAccess	spa
dc.rights.creativecommons	Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)	spa
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	spa
dc.source	https://www.sciencedirect.com/science/article/abs/pii/S0306987716000487?via%3Dihub	eng
dc.subject.proposal	Myopia	eng
dc.subject.proposal	Insulin resistance	eng
dc.title	Is myopia another clinical manifestation of insulin resistance?	eng
dc.type	Artículo de revista	spa
dc.type.coar	http://purl.org/coar/resource_type/c_6501	spa
dc.type.content	Text	spa
dc.type.driver	info:eu-repo/semantics/article	spa
dc.type.redcol	http://purl.org/redcol/resource_type/ART	spa
dc.type.version	info:eu-repo/semantics/publishedVersion	spa
dspace.entity.type	Publication
oaire.accessrights	http://purl.org/coar/access_right/c_abf2	spa
oaire.version	http://purl.org/coar/version/c_970fb48d4fbd8a85	spa