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Prognostic validation of a non-laboratory and a laboratory based cardiovascular disease risk score in multiple regions of the world

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dc.contributor.authorJoseph, Philipspa
dc.contributor.authorYusuf, Salimspa
dc.contributor.authorLee, Shun Fuspa
dc.contributor.authorIbrahim, Quazispa
dc.contributor.authorTeo, Koonspa
dc.contributor.authorRangarajan, Sumathyspa
dc.contributor.authorGupta, Rajeevspa
dc.contributor.authorRosengren, Annikaspa
dc.contributor.authorLear, Scott A.spa
dc.contributor.authorAvezum, Alvarospa
dc.contributor.authorLopez-Jaramillo, Patriciospa
dc.contributor.authorGulec, Sadispa
dc.contributor.authorYusufali, Afzalhusseinspa
dc.contributor.authorChifamba, Jephatspa
dc.contributor.authorLanas, Fernandospa
dc.contributor.authorKumar, Rajeshspa
dc.contributor.authorMohammadifard, Noushinspa
dc.contributor.authorMohan, Viswanathanspa
dc.contributor.authorMony, Premspa
dc.contributor.authorKruger, Annamariespa
dc.contributor.authorLiu, Xuspa
dc.contributor.authorGuo, Baoxiaspa
dc.contributor.authorZhao, Wenqispa
dc.contributor.authorYang, Youzhuspa
dc.contributor.authorPillai, Rajamohananspa
dc.contributor.authorDiaz, Rafaelspa
dc.contributor.authorKrishnapillai, Ambiggaspa
dc.contributor.authorIqbal, Romainaspa
dc.contributor.authorYusuf, Ritaspa
dc.contributor.authorSzuba, Andrzejspa
dc.contributor.authorAnand, Sonia S.spa
dc.date.accessioned2019-07-09T16:40:35Zspa
dc.date.available2019-07-09T16:40:35Zspa
dc.date.issued2018spa
dc.description7 p.spa
dc.description.abstractObjective To evaluate the performance of the non-laboratory INTERHEART risk score (NL-IHRS) to predict incident cardiovascular disease (CVD) across seven major geographic regions of the world. The secondary objective was to evaluate the performance of the fasting cholesterol-based IHRS (FC-IHRS). Methods Using measures of discrimination and calibration, we tested the performance of the NL-IHRS (n=100 475) and FC-IHRS (n=107 863) for predicting incident CVD in a community-based, prospective study across seven geographic regions: South Asia, China, Southeast Asia, Middle East, Europe/North America, South America and Africa. CVD was defined as the composite of cardiovascular death, myocardial infarction, stroke, heart failure or coronary revascularisation. Results Mean age of the study population was 50.53 (SD 9.79) years and mean follow-up was 4.89 (SD 2.24) years. The NL-IHRS had moderate to good discrimination for incident CVD across geographic regions (concordance statistic (C-statistic) ranging from 0.64 to 0.74), although recalibration was necessary in all regions, which improved its performance in the overall cohort (increase in C-statistic from 0.69 to 0.72, p<0.001). Regional recalibration was also necessary for the FC-IHRS, which also improved its overall discrimination (increase in C-statistic from 0.71 to 0.74, p<0.001). In 85 078 participants with complete data for both scores, discrimination was only modestly better with the FC-IHRS compared with the NL-IHRS (0.74 vs 0.73, p<0.001). Conclusions External validations of the NL-IHRS and FC-IHRS suggest that regionally recalibrated versions of both can be useful for estimating CVD risk across a diverse range of community-based populations. CVD prediction using a non-laboratory score can provide similar accuracy to laboratory-based methods.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.1136/heartjnl-2017-311609eng
dc.identifier.issn1355-6037spa
dc.identifier.issn1468-201Xspa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/3315spa
dc.language.isoengspa
dc.relation.ispartofHearteng
dc.rightsDerechos Reservados - Heart, 2018spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://heart.bmj.com/content/heartjnl/104/7/581.full.pdfeng
dc.subject.proposalcardiovascular diseaseeng
dc.subject.proposalRisk Scoreeng
dc.titlePrognostic validation of a non-laboratory and a laboratory based cardiovascular disease risk score in multiple regions of the worldeng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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