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Association of ultra-processed food intake with risk of inflammatory bowel disease. Prospective cohort study

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dc.contributor.authorNarula, Neeraj
dc.contributor.authorWong, Emily C.L.
dc.contributor.authorDehghan, Mahshid
dc.contributor.authorMente, Andrew
dc.contributor.authorRangarajan, Sumathy
dc.contributor.authorLanas, Fernando
dc.contributor.authorLopez-Jaramillo, Patricio
dc.contributor.authorRohatgi, Priyanka
dc.contributor.authorLakshmi, P. V. M.
dc.contributor.authorPrasad Varma, Ravi
dc.contributor.authorOrlandini, Andres
dc.contributor.authorAvezum, Alvaro
dc.contributor.authorWielgosz, Andreas
dc.contributor.authorPoirier, Paul
dc.contributor.authorAlmadi, Majid A.
dc.contributor.authorAltuntas, Yuksel
dc.contributor.authorNg, Kien Keat
dc.contributor.authorChifamba, Jephat
dc.contributor.authorYeates, Karen
dc.contributor.authorPuoane, Thandi
dc.contributor.authorKhatib, Rasha
dc.contributor.authorYusuf, Rita
dc.contributor.authorBengtsson Boström, Kristina
dc.contributor.authorZatonska, Katarzyna
dc.contributor.authorIqbal, Romaina
dc.contributor.authorWeida, Liu
dc.contributor.authorYibing, Zhu
dc.contributor.authorSidong, Li
dc.contributor.authorDans, Antonio
dc.contributor.authorYusufali, Afzalhussein
dc.contributor.authorMohammadifard, Noushin
dc.contributor.authorMarshall, John K.
dc.contributor.authorMoayyedi, Paul
dc.contributor.authorReinisch, Walter
dc.contributor.authorYusuf, Salim
dc.contributor.researchgroupMasiraspa
dc.date.accessioned2022-02-21T14:43:44Z
dc.date.available2022-02-21T14:43:44Z
dc.date.issued2021-07-14
dc.descriptionDigitalspa
dc.description.abstractOBJECTIVE To evaluate the relation between intake of ultraprocessed food and risk of inflammatory bowel disease (IBD). DESIGN Prospective cohort study. SETTING 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle East, south Asia, South East Asia, and China). PARTICIPANTS 116087 adults aged 35-70 years with at least one cycle of follow-up and complete baseline food frequency questionnaire (FFQ) data (country specific validated FFQs were used to document baseline dietary intake). Participants were followed prospectively at least every three years. MAIN OUTCOME MEASURES The main outcome was development of IBD, including Crohn’s disease or ulcerative colitis. Associations between ultra-processed food intake and risk of IBD were assessed using Cox proportional hazard multivariable models. Results are presented as hazard ratios with 95% confidence intervals. RESULTS Participants were enrolled in the study between 2003 and 2016. During the median follow-up of 9.7 years (interquartile range 8.9-11.2 years), 467 participants developed incident IBD (90 with Crohn’s disease and 377 with ulcerative colitis). After adjustment for potential confounding factors, higher intake of ultra-processed food was associated with a higher risk of incident IBD (hazard ratio 1.82, 95% confidence interval 1.22 to 2.72 for ≥5 servings/day and 1.67, 1.18 to 2.37 for 1-4 servings/day compared with <1 serving/day, P=0.006 for trend). Different subgroups of ultra-processed food, including soft drinks, refined sweetened foods, salty snacks, and processed meat, each were associated with higher hazard ratios for IBD. Results were consistent for Crohn’s disease and ulcerative colitis with low heterogeneity. Intakes of white meat, red meat, dairy, starch, and fruit, vegetables, and legumes were not associated with incident IBD. CONCLUSIONS Higher intake of ultra-processed food was positively associated with risk of IBD. Further studies are needed to identify the contributory factors within ultraprocessed foods. STUDY REGISTRATION ClinicalTrials.gov NCT03225586.spa
dc.description.researchareaCiencias Médicas y de la Saludspa
dc.format.extent11 pspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.arkhttps://doi.org/10.1136/bmj.n1554
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/6067
dc.language.isoengspa
dc.publisherBMJ Journalsspa
dc.publisher.placeReino Unidospa
dc.relation.citationendpage11spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume374spa
dc.relation.citesBMJ 2021;374:n1554 http://dx.doi.org/10.1136/bmj.n1554
dc.relation.indexedScopusspa
dc.relation.ispartofjournalThe BMJspa
dc.rightsThe Authors 2021spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.sourcehttps://www.bmj.com/content/374/bmj.n1554spa
dc.titleAssociation of ultra-processed food intake with risk of inflammatory bowel disease. Prospective cohort studyspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceTodas las Audienciasspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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