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Association of urinary sodium and potassium excretion with blood pressure

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dc.contributor.authorAndrew Mentespa
dc.contributor.authorMartin J. O'Donnellspa
dc.contributor.authorSumathy Rangarajanspa
dc.contributor.authorMatthew J. McQueenspa
dc.contributor.authorPaul Poirierspa
dc.contributor.authorAndreas Wielgoszspa
dc.contributor.authorHoward Morrisonspa
dc.contributor.authorWei Lispa
dc.contributor.authorXingyu Wangspa
dc.contributor.authorChen Dispa
dc.contributor.authorPrem Monyspa
dc.contributor.authorAnitha Devanathspa
dc.contributor.authorAnnika Rosengrenspa
dc.contributor.authorAytekin Oguzspa
dc.contributor.authorKatarzyna Zatonskaspa
dc.contributor.authorAfzal Hussein Yusufalispa
dc.contributor.authorLopez-Jaramillo, Patriciospa
dc.contributor.authorAlvaro Avezumspa
dc.contributor.authorNoorhassim Ismailspa
dc.contributor.authorFernando Lanasspa
dc.contributor.authorThandi Puoanespa
dc.contributor.authorRafael Diazspa
dc.contributor.authorRoya Kelishadispa
dc.contributor.authorRomaina Iqbalspa
dc.contributor.authorRita Yusufspa
dc.contributor.authorJephat Chifambaspa
dc.contributor.authorRasha Khatibspa
dc.contributor.authorKoon Teospa
dc.contributor.authorSalim Yusufspa
dc.contributor.authorThe PURE Investigatorseng
dc.date.accessioned2019-08-08T14:10:43Zspa
dc.date.available2019-08-08T14:10:43Zspa
dc.date.issued2014-08-14spa
dc.description11 pspa
dc.description.abstractBackground Higher levels of sodium intake are reported to be associated with higher blood pressure. Whether this relationship varies according to levels of sodium or potas- sium intake and in different populations is unknown.Methods We studied 102,216 adults from 18 countries. Estimates of 24-hour sodium and potassium excretion were made from a single fasting morning urine specimen and were used as surrogates for intake. We assessed the relationship between electro- lyte excretion and blood pressure, as measured with an automated device. Results: Regression analyses showed increments of 2.11 mm Hg in systolic blood pressure and 0.78 mm Hg in diastolic blood pressure for each 1-g increment in estimated sodium excretion. The slope of this association was steeper with higher sodium intake (an increment of 2.58 mm Hg in systolic blood pressure per gram for sodium excretion >5 g per day, 1.74 mm Hg per gram for 3 to 5 g per day, and 0.74 mm Hg per gram for <3 g per day; P<0.001 for interaction). The slope of association was steeper for persons with hypertension (2.49 mm Hg per gram) than for those with- out hypertension (1.30 mm Hg per gram, P<0.001 for interaction) and was steeper with increased age (2.97 mm Hg per gram at >55 years of age, 2.43 mm Hg per gram at 45 to 55 years of age, and 1.96 mm Hg per gram at <45 years of age; P<0.001 for interaction). Potassium excretion was inversely associated with systolic blood pressure, with a steeper slope of association for persons with hypertension than for those without it (P<0.001) and a steeper slope with increased age (P<0.001). Conclusions In this study, the association of estimated intake of sodium and potassium, as de- termined from measurements of excretion of these cations, with blood pressure was nonlinear and was most pronounced in persons consuming high-sodium diets, persons with hypertension, and older persons. (Funded by the Heart and Stroke Foundation of Ontario and others.)eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.1056/NEJMoa1311989spa
dc.identifier.issn1533-4406spa
dc.identifier.issn0028-4793spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/3543spa
dc.language.isoengspa
dc.relation.ispartofNew England Journal of Medicineeng
dc.rightsDerechos Reservados - The Authors, New England Journal of Medicine, 2014spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://www.researchgate.net/publication/264793827_Association_of_Urinary_Sodium_and_Potassium_Excretion_with_Blood_Pressure/link/53f4c86a0cf22be01c3edfb8/downloadeng
dc.subject.proposalUrinary sodiumeng
dc.subject.proposalPotassium excretioneng
dc.subject.proposalBlood pressureeng
dc.titleAssociation of urinary sodium and potassium excretion with blood pressureeng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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