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In vitro antimicrobial effect of chloroaluminum phthalocyanine nanoemulsion on periodontal bacteria

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dc.contributor.authorLloreda-Rey, Laura Patricia
dc.contributor.authorLeal-Pinto, Sandra Milena
dc.contributor.authorMuelhmann, Luis Alexandre
dc.contributor.authorMéndez, Luz Mery
dc.contributor.authorHerrera Sandoval, Laura Viviana
dc.contributor.researchgroupCliniUDESspa
dc.date.accessioned2022-03-02T15:04:09Z
dc.date.available2022-03-02T15:04:09Z
dc.date.issued2021-05-04
dc.descriptionDigitalspa
dc.description.abstractContext: Nowadays, complementary therapies are necessary for a major removal of microbial subgingival biofilm in the conventional treatment of periodontitis. Research has suggested the use of photodynamic therapy (PDT) as a promising therapy to manage oral cavity infections. This project proposes a new combination of photosensitizer chloroaluminum phthalocyanine and nanoemulsion as a strategy for improving bioactivity. The main purpose of this in vitro study was to evaluate the antimicrobial activity of nanoemulsion ClAlPc (ClAlPc-NE) on relevant periodontal bacteria before and after PDT. Materials and Methods: The phototoxic and antibacterial effect of ClAlPc-NE was evaluated against epithelial cells derived from an African green monkey kidney using the colorimetric method with salt tetrazolium 3-(4.5-dimethylthiazolyl-2)-2.5-Diphenyltetrazolium bromide (Merck) and periodontopathogen bacteria (Porphyromonas gingivalis (ATCC 33277), Aggregatibacter actinomycetemcomitans (ATCC 33384), and Prevotella intermedia (ATCC 25611) using the plate microdilution method according to Tavares et al., 2018, respectively. The light source used for the PDT was a LED laser (400–700 nm); the cells were irradiated for 2 min using 4.83 joules/cm2. Results: Antibacterial effect of NE-PcAlCl against P. intermedia with minimum inhibitory concentration (MIC) 0.63 μM after TFD was determined. In the case of P. gingivalis and A. actinomycetemcomitans, no biological activity was found after PDT (MIC > 20 μM) under-evaluated experimental conditions. On the other hand, the ClAlPc-free and ClAlPc-NE cells were phototoxic on epithelial cells. Conclusion: The results helped to identify the potential use of ClAlPc-NE to inhibit the periodontal bacterial and additional studies are being developed.spa
dc.description.researchareaCiencias Médicas y de la Saludspa
dc.format.extent3 pspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.4103/jisp.jisp_433_20
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/6216
dc.language.isoengspa
dc.publisher.placeIndiaspa
dc.relation.citationendpage269spa
dc.relation.citationissue3spa
dc.relation.citationstartpage267spa
dc.relation.citationvolume25spa
dc.relation.citesRey, L., Pinto, S., Muelhmann, L. A., Méndez, L. M., & Sandoval, L. (2021). In vitro antimicrobial effect of chloroaluminum phthalocyanine nanoemulsion on periodontal bacteria. Journal of Indian Society of Periodontology, 25(3), 267–269. https://doi.org/10.4103/jisp.jisp_433_20
dc.relation.indexedScopusspa
dc.relation.ispartofjournalJournal of Indian Society of Periodontologyspa
dc.rightsCopyright: © 2021 Indian Society of Periodontology.spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución 4.0 Internacional (CC BY 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/spa
dc.sourcehttps://www.jisponline.com/article.asp?issn=0972-124X;year=2021;volume=25;issue=3;spage=267;epage=269;aulast=Reyspa
dc.subject.proposalAntimicrobial activityeng
dc.subject.proposalNanoemulsioneng
dc.subject.proposalPeriodontal bacteriaeng
dc.subject.proposalPeriodontitiseng
dc.subject.proposalPhotodynamic therapyeng
dc.subject.proposalPhthalocyanineeng
dc.titleIn vitro antimicrobial effect of chloroaluminum phthalocyanine nanoemulsion on periodontal bacteriaspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceTodas las Audienciasspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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