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Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity Evaluations

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dc.contributor.authorLeal-Pinto, Sandra Milenaspa
dc.contributor.authorRoa Cordero, Martha Vivianaspa
dc.contributor.authorNagles, Edgarspa
dc.contributor.authorMuñoz Castro, Alvarospa
dc.contributor.authorHurtado, John J.spa
dc.contributor.authorMurcia, Ricardo A.spa
dc.date.accessioned2019-06-20T13:15:22Zspa
dc.date.available2019-06-20T13:15:22Zspa
dc.date.issued2018-08-13spa
dc.description16 p.spa
dc.description.abstractIn this work, six complexes (2–7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3–7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL−1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.3390/molecules23082013spa
dc.identifier.issn1420-3049spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/3167spa
dc.language.isoengspa
dc.relation.ispartofMoleculesspa
dc.rightsDerechos Reservados - Universidad de Santander, 2018spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://www.mdpi.com/1420-3049/23/8/2013spa
dc.subject.proposalTriazole ligandsspa
dc.subject.proposalCobalt(II) and chromium(III) complexesspa
dc.subject.proposalAntibacterial activityspa
dc.subject.proposalAntifungal activityspa
dc.titleDevelopment of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes : Synthesis and Biological Activity Evaluationsspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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