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Increased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvi

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dc.contributor.authorRueda Clausen, Christian F.spa
dc.contributor.authorCórdoba Porras, A.spa
dc.contributor.authorBedoya, G.spa
dc.contributor.authorSilva Sieger, Federico Arturospa
dc.contributor.authorZarruk, Juan G.spa
dc.contributor.authorLopez-Jaramillo, Patriciospa
dc.contributor.authorVilla, L.A.spa
dc.date.accessioned2019-08-27T16:07:40Zspa
dc.date.available2019-08-27T16:07:40Zspa
dc.date.issued2012-03spa
dc.description9 p.spa
dc.description.abstractBACKGROUND AND PURPOSE:Despite sharing some metabolic and pathological mechanisms, the reported association between total homocysteine (tHcy), asymmetric dimethylarginine (ADMA) and stroke remains controversial, particularly in Hispanic populations from developing countries in which genetic, socioeconomic, and nutritional factors are different to those described in developed countries. Our objectives were to determine the relationships of these factors to stroke and to each other independent of other cardiovascular risk factors, and to explore potential sex differences. METHODS: This national (Colombia) multicenter case-control study included 238 cases and 238 controls to evaluate traditional and emerging risk factors for ischemic stroke including tHcy and ADMA plasma levels. RESULTS: The median plasma levels of tHcy were 8.48 μM for controls and 10.01 μM for cases (P<0.0001). Plasma levels of tHcy between 12 and 50μM were considered moderate hyperhomocysteinemia (HtHcy). There were no differences in plasma ADMA concentration between groups (P=0.40). Plasma levels of ADMA and creatinine were not correlated (P=0.47). After adjusting for confounding factors, the presence of HtHcy was strongly associated with stroke (OR 8.97; P<0.0001). The adjusted association between HtHcy and stroke in men (OR 9.98) was comparable to that in women (OR 8.98) (P=0.41). CONCLUSIONS: In this Hispanic population, with relatively normal renal function, plasma levels of tHcy but not ADMA were associated with stroke independent of other cardiovascular risk factors.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.1111/j.1468-1331.2011.03534.xspa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/3654spa
dc.language.isoengspa
dc.relation.ispartofEuropean Journal of Neurologyeng
dc.relation.ispartofseriesEuropean Journal of Neurology;Volume19, Issue3 March 2012 Pages 417-425eng
dc.rightsDerechos Reservados - The Authors, European Journal of Neurology, 2012spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1468-1331.2011.03534.xeng
dc.subject.proposalAssociationeng
dc.subject.proposalAsymmetric Dimethylarginineeng
dc.subject.proposalHispanic hyperhomocysteinemiaeng
dc.subject.proposalStrokeeng
dc.titleIncreased plasma levels of total homocysteine but not asymmetric dimethylarginine in hispanic subjects with ischemic stroke frecvieng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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