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Cross-tolerance between nitric oxide synthase inhibition and atypical antipsychotics modify nicotinamide-adenine-dinucleotide phosphate-diaphorase activity in mouse lateral striatum

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dc.contributor.authorPrieto, Sonia G.
dc.contributor.authorSilva, João C.S.
dc.contributor.authorDe Lima, Mairon O.
dc.contributor.authorAlmeida, Maria C.
dc.contributor.authorEcheverry, Marcela B.
dc.contributor.researchgroupNeuro Cienciasspa
dc.date.accessioned2022-05-09T16:15:24Z
dc.date.available2022-05-09T16:15:24Z
dc.date.issued2019-02-05
dc.descriptionDigitalspa
dc.description.abstractPrevious research indicates that the subchronic administration of NG-nitro-L-arginine (L-NOARG) produces tolerance to haloperidol-induced catalepsy in Swiss mice. The present study aimed to further investigate whether intermittent subchronic systemic administration of L-NOARG induces tolerance to the cataleptic effects of haloperidol as well as olanzapine or clozapine (Clz) in C57Bl mice after subchronic administration for 5 consecutive days. Striatal FosB protein expression was measured in an attempt to gain further insights into striatal mechanisms in antipsychotic-induced extrapyramidal symptoms side effects. An nicotinamide-adenine-dinucleotide phosphate-diaphorase histochemical reaction was also used to investigate whether tolerance could induce changes in the number of nitric oxide synthase-active neurons. Subchronic administration of all antipsychotics produced catalepsy, but cross-tolerance was observed only between L-NOARG (15 mg/kg, intraperitoneally) and Clz (20 mg/kg, intraperitoneally). This cross-tolerance effect was accompanied by decreased FosB protein expression in the dorsal striatum and the nucleus accumbens shell region, and reduced icotinamide-adenine-dinucleotide phosphate-diaphorase activity in the dorsal and ventral lateral striatum. Overall, these results suggest that interference with the formation of nitric oxide, mainly in the dorsal and ventral lateral-striatal regions, appears to improve the cataleptic effects induced by antipsychotics acting as antagonists of low-affinity dopamine D2 receptor, such as Clz.eng
dc.description.researchareaCiencias Médicas y de la Saludspa
dc.format.extent12 pspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.1097/FBP.0000000000000406
dc.identifier.eissn1473-5849spa
dc.identifier.issn0955-8810spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/6735
dc.language.isoengspa
dc.publisher.placeUSAspa
dc.relation.citationendpage78spa
dc.relation.citationissue1spa
dc.relation.citationstartpage67spa
dc.relation.citationvolume30spa
dc.relation.citesPrieto, Sonia, Silva, Joao, de Lima, Mairon, Almeida, Maria & Echeverry, Marcela. (2019). Cross-tolerance between nitric oxide synthase inhibition and atypical antipsychotics modify nicotinamide-adenine-dinucleotide phosphate-diaphorase activity in mouse lateral striatum. Behavioural Pharmacology, 30, 67-78. https://doi.org/10.1097/FBP.0000000000000406
dc.relation.indexedScopusspa
dc.relation.ispartofjournalBehavioural Pharmacologyspa
dc.rightsCopyright © 2019 Wolters Kluwer Health, Inc. All rights reservedspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://ovidsp.dc2.ovid.com/ovid-b/ovidweb.cgi?WebLinkFrameset=1&S=CIFFFPFMAOEBGIGPJPNJLEIHHENMAA00&returnUrl=ovidweb.cgi%3f%26Complete%2bReference%3dS.sh.22%257c1%257c1%26FORMAT%3dcitationFormatPrint%26FIELDS%3dFORMATl%26S%3dCIFFFPFMAOEBGIGPJPNJLEIHHENMAA00&fromjumpstart=0&directlink=https%3a%2f%2fovidsp.dc2.ovid.com%2fovftpdfs%2fFPEBJPIHLEGPAO00%2ffs046%2fovft%2flive%2fgv023%2f00008877%2f00008877-201902000-00007.pdf&filename=Cross-tolerance+between+nitric+oxide+synthase+inhibition+and+atypical+antipsychotics+modify+nicotinamide-adenine-dinucleotide+phosphate-diaphorase+activity+in+mouse+lateral+striatum.&navigation_links=NavLinks.S.sh.22.1&PDFIdLinkField=%2ffs046%2fovft%2flive%2fgv023%2f00008877%2f00008877-201902000-00007&link_from=S.sh.22%7c1&pdf_key=B&pdf_index=S.sh.22&D=ovftspa
dc.subject.proposalClozapineeng
dc.subject.proposalDorsal lateral striatumeng
dc.subject.proposalFosBeng
dc.subject.proposalHaloperidoleng
dc.subject.proposalNeuronal nitric oxide synthaseeng
dc.subject.proposalNG-nitro-L-arginineeng
dc.subject.proposalOlanzapineeng
dc.subject.proposalRateng
dc.subject.proposalVentral lateral striatumeng
dc.titleCross-tolerance between nitric oxide synthase inhibition and atypical antipsychotics modify nicotinamide-adenine-dinucleotide phosphate-diaphorase activity in mouse lateral striatumspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceTodas las Audienciasspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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