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Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption

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dc.contributor.authorRadiske, Andressa
dc.contributor.authorGonzalez, Maria Carolina
dc.contributor.authorConde-Ocazionez, Sergio A.
dc.contributor.authorRossato, Janine I.
dc.contributor.authorKöhler, Cristiano A.
dc.contributor.authorCammarota, Martín
dc.contributor.researchgroupNeuro Cienciasspa
dc.date.accessioned2022-05-09T15:58:43Z
dc.date.available2022-05-09T15:58:43Z
dc.date.issued2020-08-12
dc.descriptionDigitalspa
dc.description.abstractAvoidance memory reactivation at recall triggers theta-gamma hippocampal phase amplitude coupling (hPAC) only when it elicits hippocampus-dependent reconsolidation. However, it is not known whether there is a causal relationship between these phenomena. We found that in adult male Wistar rats, silencing the medial septum during recall did not affect avoidance memory expression or maintenance but abolished hPAC and the amnesia caused by the intrahippocampal administration of reconsolidation blockers, both of which were restored by concomitant theta burst stimulation of the fimbria–fornix pathway. Remarkably, artificial hPAC generated by fimbria–fornix stimulation during recall of a learned avoidance response naturally resistant to hippocampus-dependent reconsolidation made it susceptible to reactivation-dependent amnesia. Our results indicate that hPAC mediates the destabilization required for avoidance memory reconsolidation and suggest that the generation of artificial hPAC at recall overcomes the boundary conditions of this process.eng
dc.description.researchareaCiencias Médicas y dela Saludspa
dc.format.extent11 pspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1523/JNEUROSCI.0259-20.2020
dc.identifier.eissn1529-2401spa
dc.identifier.issn0270-6474spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/6733
dc.language.isoengspa
dc.publisher.placeUSAspa
dc.relation.citationendpage6408spa
dc.relation.citationissue33spa
dc.relation.citationstartpage6398spa
dc.relation.citationvolume40spa
dc.relation.citesAndressa Radiske, Maria Carolina Gonzalez, Sergio Conde-Ocazionez, Janine I. Rossato, Cristiano A. Köhler, Martín Cammarota Journal of Neuroscience 12 August 2020, 40 (33) 6398-6408; DOI: 10.1523/JNEUROSCI.0259-20.2020
dc.relation.indexedScopusspa
dc.relation.ispartofjournalJournal of Neurosciencespa
dc.rightsCopyright © 2020 The Authorsspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución 4.0 Internacional (CC BY 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/spa
dc.sourcehttps://www.jneurosci.org/content/jneuro/40/33/6398.full.pdfspa
dc.subject.proposalC/EBPbeng
dc.subject.proposalDeep brain stimulationeng
dc.subject.proposalFeareng
dc.subject.proposalForgettingeng
dc.subject.proposalPTSDspa
dc.subject.proposalRetrievalspa
dc.titleCross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruptionspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceTodas las Audienciasspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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