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Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea

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dc.contributor.authorGarcía, Ronald G.spa
dc.contributor.authorKim, Jieunspa
dc.contributor.authorSheehan, James D.spa
dc.contributor.authorBeissner, Florianspa
dc.contributor.authorBianchi, Anna M.spa
dc.contributor.authorCerutti, Sergiospa
dc.contributor.authorKuo, Bradenspa
dc.contributor.authorBarbieri, Riccardospa
dc.contributor.authorNapadow, Vitalyspa
dc.contributor.authorSclocco, Robertaspa
dc.date.accessioned2019-07-02T13:08:39Zspa
dc.date.available2019-07-02T13:08:39Zspa
dc.date.issued2016-02spa
dc.description13 p.spa
dc.description.abstractWhile autonomic outflow is an important co-factor of nausea physiology, central control of this outflow is poorly understood. We evaluated sympathetic (skin conductance level) and cardiovagal (high-frequency heart rate variability) modulation, collected synchronously with functional MRI (fMRI) data during nauseogenic visual stimulation aimed to induce vection in susceptible individuals. Autonomic data guided analysis of neuroimaging data, using a stimulus-based (analysis windows set by visual stimulation protocol) and percept-based (windows set by subjects’ ratings) approach. Increased sympathetic and decreased parasympathetic modulation was associated with robust and anti-correlated brain activity in response to nausea. Specifically, greater autonomic response was associated with reduced fMRI signal in brain regions such as the insula, suggesting an inhibitory relationship with premotor brainstem nuclei. Interestingly, some sympathetic/parasympathetic specificity was noted. Activity in default mode network and visual motion areas was anti-correlated with parasympathetic outflow at peak nausea. In contrast, lateral prefrontal cortical activity was anticorrelated with sympathetic outflow during recovery, soon after cessation of nauseogenic stimulation. These results suggest divergent central autonomic control for sympathetic and parasympathetic response to nausea. Autonomic outflow and the central autonomic network underlying ANS response to nausea may be an important determinant of overall nausea intensity and, ultimately, a potential therapeutic target.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.1093/cercor/bhu172eng
dc.identifier.isbn1460-2199spa
dc.identifier.issn1047-3211spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/3241spa
dc.language.isoengspa
dc.relation.ispartofCerebral Cortexeng
dc.rightsDerechos Reservados - Universidad de Santander, 2016spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://watermark.silverchair.com/bhu172.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAkEwggI9BgkqhkiG9w0BBwagggIuMIICKgIBADCCAiMGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMy-2qEYYrFUUV3eATAgEQgIIB9In72CfRT54L5wtynd9F_Mm06XrM4lOgIqeuSUuPL10CbjZ9QSQ_T5s76ZhVL6mu6e_33jAgyc9XE7vGBLCjT0ikeDklrP6RLdLkoSbV0jftJFC7ZVak9f_iksNZ-rCBBfXsRLWKIxchSHkO-b-w23Wy1yuL1w21rr-kfNxfG_JIxYWmcDM9Jt9lccJ_VGJbkpSlwrOszCegQBvGLMT29TQ3Xep8ynijxd2Rmgjn8EcbFdY9b6wx-KTi6o5RaAim8JDzVe1Ox2ccq3O8x1ETcM12Wfnv3xlxQa5LbjZD1OVC-ZwHUwiBaB-6Rtk6KPEmitcFmtkGwJ8SLZzjw4TFCFC073RJsd2utozvZiR4j52ZC34gQHymg4VjDWos_I7CbLosJjpXtHVId6E6bhUrWz9x7xhBhvpns02zdNlunQlJ2F4K37Rm0K2gzMsvkwDkgzGcgt1ndHo2cvKnMVqEcRE7WUHelG_6Kqr-J0vJFOJv5erXza_W7o_6IqD1pE-sjYJ6yDMF5U2SaJkRq_dpuEpCTw5pKV7YLeXRStDyfn7gUcvf9q-5xeuOu8B4pkXrHeMLrT0xDpe_jI47OhMnm8nLeANIdQHtKF9Ki0e2-m83XdIQPKLsJ-U_sSErOggRP4fbUgYcuLylTPuuFgmxR0gEUXR-eng
dc.subject.proposalBrain–gut interactionseng
dc.subject.proposalMotion sicknesseng
dc.subject.proposalNeuroimagingeng
dc.subject.proposalParasympatheticeng
dc.subject.proposalSympatheticeng
dc.titleBrain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nauseaeng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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