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Genetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity

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dc.contributor.authorSuarez-Barrera, Miguel Orlando
dc.contributor.authorVisser, Lydia
dc.contributor.authorRondon-Villarreal, Paola
dc.contributor.authorHerrera-Pineda, Diego Fernando
dc.contributor.authorAlarcon-Aldana, Juan S.
dc.contributor.authorVan den Berg, Anke
dc.contributor.authorOrozco, Jahir
dc.contributor.authorPinzon- Reyes, Efrain-Hernando
dc.contributor.authorMoreno, Ernesto
dc.contributor.authorRueda Forero, Nohora Juliana
dc.contributor.researchgroupMasiraspa
dc.date.accessioned2022-02-25T14:09:50Z
dc.date.available2022-02-25T14:09:50Z
dc.date.issued2021-12-10
dc.descriptionDigitalspa
dc.description.abstractBacillus thuringiensis (Bt) is a bacterium capable of producing Cry toxins, which are recognized for their bio-controlling actions against insects. However, a few Bt strains encode proteins lacking insecticidal activity but showing cytotoxic activity against different cancer cell lines and low or no cytotoxicity toward normal human cells. A subset of Cry anticancer proteins, termed parasporins (PSs), has recently arisen as a potential alternative for cancer treatment. However, the molecular receptors that allow the binding of PSs to cells and their cytotoxic mechanisms of action have not been well established. Nonetheless, their selective cytotoxic activity against different types of cancer cell lines places PSs as a promising alternative treatment modality. In this review, we provide an overview of the classification, structures, mechanisms of action, and insights obtained from genetic modification approaches for PS proteins.spa
dc.description.researchareaCiencias Médicas y de la Saludspa
dc.format.extent13 pspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.3390/molecules26247476
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/6160
dc.language.isoengspa
dc.publisherMDPIspa
dc.publisher.placeUSAspa
dc.relation.citationendpage13spa
dc.relation.citationissue24spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume26spa
dc.relation.citesSuárez-Barrera, M.O.; Visser, L.; Rondón-Villarreal, P.; Herrera-Pineda, D.F.; Alarcón-Aldana, J.S.; Van den Berg, A.; Orozco, J.; Pinzón-Reyes, E.H.; Moreno, E.; Rueda-Forero, N.J. Genetic Modification Approaches for Parasporins Bacillus thuringiensis Proteins with Anticancer Activity. Molecules 2021, 26, 7476. https:// doi.org/10.3390/molecules26247476
dc.relation.indexedScopusspa
dc.relation.ispartofjournalMoleculesspa
dc.rightsCopyright: © 2021 by the authorsspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttps://www.mdpi.com/1420-3049/26/24/7476spa
dc.subject.proposalParasporinseng
dc.subject.proposalCry toxinseng
dc.subject.proposalCancer cellseng
dc.subject.proposalGenetic improvementeng
dc.titleGenetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activityspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceTodas las Audienciasspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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