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Risk of dengue virus infection according to serostatus in individuals from dengue endemic areas of Mexico

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dc.contributor.authorAmaya-Larios, I. Y.
dc.contributor.authorMartinez-Vega, Ruth Arali
dc.contributor.authorDiaz-Quijano, F. A.
dc.contributor.authorSarti, E.
dc.contributor.authorPuentes-Rosas, E.
dc.contributor.authorChihu, L.
dc.contributor.authorRamos-Castañeda, J.
dc.contributor.researchgroupSalud Comuniudesspa
dc.date.accessioned2022-05-17T17:06:13Z
dc.date.available2022-05-17T17:06:13Z
dc.date.issued2020-11-04
dc.descriptionDigitalspa
dc.description.abstractThe variability in the host immune response directed against dengue virus (DENV) has demonstrated the need to understand the immune response associated with protection in incident infection. The objective was to estimate the association between serostatus and the risk of incident DENV infection. We used a prospective study from 2014 to 2016 in the localities of Axochiapan and Tepalcingo, Morelos, Mexico. We recruited 966 participants, of which, according to their infection history registered were categorized in four groups. To accomplish the objectives of this study, we selected to 400 participants older than 5 years of age were followed for 2.5 years. Blood samples were taken every 6 months to measure serological status and infection by ELISA. In individuals with at least two previous infections the risk of new infection was lower compared to a seronegative group (hazard ratio adjusted 0.49, 95% CI 0.24–0.98), adjusted for age and locality. Therefore, individuals who have been exposed two times or more to a DENV infection have a lower risk of re-infection, thus showing the role of cross-immunity and its association with protection.eng
dc.description.researchareaCiencias Médicas y de la Saludspa
dc.format.extent9 pspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41598-020-75891-z
dc.identifier.eissn2045-2322spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/6840
dc.language.isoengspa
dc.publisher.placeReino Unidospa
dc.relation.citationendpage10spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume10spa
dc.relation.citesAmaya-Larios, I.Y., Martínez-Vega, R.A., Diaz-Quijano, F.A. et al. Risk of dengue virus infection according to serostatus in individuals from dengue endemic areas of Mexico. Sci Rep 10, 19017 (2020). https://doi.org/10.1038/s41598-020-75891-z
dc.relation.indexedScopusspa
dc.relation.ispartofjournalScientific Reportsspa
dc.rights© The Author(s) 2020spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución 4.0 Internacional (CC BY 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/spa
dc.sourcehttps://www.nature.com/articles/s41598-020-75891-z.pdfspa
dc.titleRisk of dengue virus infection according to serostatus in individuals from dengue endemic areas of Mexicospa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceTodas las Audienciasspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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