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Reactivation-dependent amnesia for object recognition memory is contingent on hippocampal theta–gamma coupling during recall

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dc.contributor.authorGonzalez, Maria Carolina
dc.contributor.authorRadiske, Andressa
dc.contributor.authorConde-Ocazionez, Sergio A.
dc.contributor.authorRossato, Janine I.
dc.contributor.authorBevilaqua, Lia R. M.
dc.contributor.authorCammarota, Martín
dc.contributor.researchgroupNeurocienciasspa
dc.date.accessioned2022-08-12T15:48:11Z
dc.date.available2022-08-12T15:48:11Z
dc.date.issued2021-12-15
dc.descriptionDigitalspa
dc.description.abstractHippocampal dopamine D1/D5 receptor-dependent destabilization is necessary for object recognition memory (ORM) updating through reconsolidation. Dopamine also regulates hippocampal theta and gamma oscillations, which are involved in novelty and memory processing. We found that, in adult male rats, ORM recall in the presence of a novel object, but not in the presence of a familiar one, triggers hippocampal theta-gamma coupling. Hippocampal theta-gamma coupling (hPAC) does not happen when ORM destabilization is prevented by blocking D1/D5 receptors, but artificial hPAC generation during recall in the presence of a familiar object enables the amnesic effect of reconsolidation inhibitors. Therefore, hPAC controls ORM destabilization, and its modulation could increase reconsolidation-based psychotherapy efficacy.spa
dc.description.researchareaCiencias Médicas y de la Saludspa
dc.format.extent6 pspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.1101/lm.053482.121.
dc.identifier.eissn1072-0502spa
dc.identifier.issn1549-5485spa
dc.identifier.urihttps://repositorio.udes.edu.co/handle/001/7390
dc.language.isoengspa
dc.publisher.placeUSAspa
dc.relation.citationendpage6spa
dc.relation.citationissue1spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume29spa
dc.relation.indexedScopusspa
dc.relation.ispartofjournalLearning & memory (Cold Spring Harbor, N.Y.)spa
dc.rights© 2022 Gonzalez et al.; Published by Cold Spring Harbor Laboratory Press.spa
dc.rights.accessrightsinfo:eu-repo/semantics/closedAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourcehttp://learnmem.cshlp.org/content/29/1/1spa
dc.titleReactivation-dependent amnesia for object recognition memory is contingent on hippocampal theta–gamma coupling during recallspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceTodas las Audienciasspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_14cbspa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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