AGBAA. Artículos de Investigación

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Examinando AGBAA. Artículos de Investigación por Autor "Cárdenas Sierra, Denny-Miley"

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  • Publicación
    Acceso abierto
    Biological activity of sacha inchi (Plukenetia volubilis linneo) and potential uses in human health. A review
    (Food Technology and Biotechnology, 2021-07-13) Cárdenas Sierra, Denny-Miley; Gómez Rave, Lyz Jenny; Soto, Javier-Andres; Biogen
    Sacha inchi (Plukenetia volubilis Linneo) is an ancestral plant originating in the Amazon jungle that has been adopted as a food source due to its high nutritional value, which has gradually been recognized to have potential benefits for human health. Diverse prospective studies have evaluated the effect of consuming components from the plant, derivatives from its seeds, leaves and shell on preventing the risk of cardiovascular disease, chronic inflammatory disease, dermatitis and controlling tumor proliferation, especially given its recognized high content of essential fatty acids, phenolic compounds and vitamin E, showing antioxidant, hypolipidemic, immunomodulation and emollient activity, as well as the capacity to remove heavy metals from aqueous solutions. This review offers a complete description of the existing information on the use and biological activity of P. volubilis L., based on its essential lipid components and evidenced on its use in the field of human health, in prevention, therapeutic and nutritional contexts, along with industrial uses, making it a promising bioresource.
  • Publicación
    Acceso abierto
    Conocimiento, actitudes y prácticas frente al VIH/SIDA en estudiantes de bachillerato de Cúcuta, Norte de Santander, Colombia
    (Archivos Venezolanos de Farmacologia y Terapeutica, 2019-01-02) Villafaña Angarita, Tatiana Maybeth; Sierra Leiva, Jahury-Estefanny; Parada, Holver-Smith; Soto, Javier-Andrés; Cárdenas Sierra, Denny-Miley
    Objetivo. Determinar el nivel de conocimientos, actitudes y prácticas acerca del VIH y SIDA en adolescentes. Métodos. Estudio correlacional de campo en 318 estudiantes de 13-21 años de edad, de noveno-undécimo de bachillerato de dos Instituciones Educativas representativas de la ciudad de Cúcuta, mediante muestreo probabilístico. Se implementó instrumento CAP validado y ficha sociodemográfica, para análisis descriptivo y correlacional. Resultados. Se registró desconocimiento sobre transmisión, población susceptible y estabilidad de preservativos en 5-47% de los estudiantes, obteniéndose un nivel bajo para la dimensión conocimiento, en contraste con actitudes y prácticas adecuadas. Conclusiones. No se encontró asociación entre variables edad, sexo, estrato, tipo familiar o escolaridad con las dimensiones de los conocimientos, actitudes o prácticas, hallándose homogeneidad en la muestra, lo que la proyecta como un grupo modelo a contrastar en futuros estudios con otras poblaciones buscando identificar aspectos mejorables en torno a estrategias de prevención global de la pandemia.
  • Publicación
    Acceso abierto
    Immunological Memory to Zika Virus in a University Community in Colombia, South America
    (2020-05-29) Cárdenas Sierra, Denny-Miley; Jaimes, Miguel A.; Vega, Leidy D.; Oliveros, Nicolas L.; Soto, Javier-Andrés; Chía, Claudia R.; Osorio, Jorge E.; Ciuoderis, Karl A.
    Zika virus appeared in South America in 2015, generating alarm worldwide as it causes microcephaly and autoimmunity. This study aims to determine the serological footprint of the incoming epidemic in a student community and to characterize the memory functional cell response during post convalescence. In a cross-sectional study, Zika-specific IgG using LIA immunoassay was found in 328 university students (CI=95%), while in the second phase, the functional cellular memory response for IFN-γ and IL-2 was quantified using post-stimulus ELISpot with inactivated virus, starting with individuals seropositive for Zika and control individuals (seropositive only for Dengue and seronegative for Zika-Dengue). Depending on the antigen used, memory humoral response (IgG) against Zika Virus was observed in >60% of the population; seropositivity for NS1 was 21.1% higher than E antigen with high intensity. The analysis of cell functionality in 22 individuals seropositive for Zika virus revealed either IFN-γ+ or IL-2+ cells in 86.3% of cases (Th1 profile), presenting multifunctionality in 50% (11 individuals), 64% of which presented> 6 SFC/104 PBMCs (>600 SFC/106 PBMC), reflecting memory circulating cells. A good agreement (Kappa= 0.754) was observed between the coexistence of both cellular and humoral responses but not in their intensity.