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- PublicaciónAcceso abiertoThe 20 × 20 Latin American society of hypertension target(2015-01) Lopez-Jaramillo, Patricio; Molina, Dora I.
- PublicaciónAcceso abiertoA bioinspired peptide in tir protein as recognition molecule on electrochemical biosensors for the detection of e. Coli o157:H7 in an aqueous matrix(Sulka, Grzegorz D., 2021-04-28) Ropero-Vega, Jose Luis; Redondo-Ortega, Joshua Felipe; Galvis-Curubo, Yuli Juliana; Rondon-Villarreal, Paola; Florez-Castillo, Johanna Marcela; CibasCurrently, the detection of pathogens such as Escherichia coli through instrumental alternatives with fast response and excellent sensitivity and selectivity are being studied. Biosensors are systems consisting of nanomaterials and biomolecules that exhibit remarkable properties such as simplicity, portable, affordable, user‑friendly, and deliverable to end‑users. For this, in this work we report for the first time, to our knowledge, the bioinformatic design of a new peptide based on TIR protein, a receptor of Intimin membrane protein which is characteristic of E. coli. This peptide (named PEPTIR‑1.0) was used as recognition element in a biosensor based on AuNPs‑modified screen‑printed electrodes for the detection of E. coli. The morphological and electrochemical characteristics of the biosensor obtained were studied. Results show that the biosensor can detect the bacteria with limits of detection and quantification of 2 and 6 CFU/mL, respectively. Moreover, the selectivity of the system is statistically significant towards the detection of the pathogen in the presence of other microorganisms such as P. aeruginosa and S. aureus. This makes this new PEPTIR‑1.0 based biosensor can be used in the rapid, sensitive, and selective detection of E. coli in aqueous matrices.
- PublicaciónAcceso abiertoA Commentary on “COVID-19 impact on Surgical Training and Recovery Planning (COVID-STAR) - A cross-sectional observational study”(2021-05-05) Ojeda-Gutiérrez, Andrés Mauricio; Quiroz-Martínez, María Bernarda; Ortega-Sierra, Michael Gregorio; Mendoza-Castillo, Luis Francisco; Lozada-Martínez, Ivan David; Salud Comuniudes
- PublicaciónAcceso abiertoA community-based comprehensive intervention to reduce cardiovascular risk in hypertension (HOPE 4)(2019-10-05) Schwalm, Jon-David; McCready, Tara; Lopez-Jaramillo, Patricio; Yusoff, Khalid; Attaran, Amir; Lamelas, Pablo; Camacho López, Paul Anthony; Majid, Fadhlina; Bangdiwala, Shrikant I.; Thabane, Lehana; Islam, Shofiqul; McKee, Martin; Yusuf, Salim; EverestBackground Hypertension is the leading cause of cardiovascular disease globally. Despite proven benefits, hypertension control is poor. We hypothesised that a comprehensive approach to lowering blood pressure and other risk factors, informed by detailed analysis of local barriers, would be superior to usual care in individuals with poorly controlled or newly diagnosed hypertension. We tested whether a model of care involving non-physician health workers (NPHWs), primary care physicians, family, and the provision of effective medications, could substantially reduce cardiovascular disease risk. Methods HOPE 4 was an open, community-based, cluster-randomised controlled trial involving 1371 individuals with new or poorly controlled hypertension from 30 communities (defined as townships) in Colombia and Malaysia. 16 communities were randomly assigned to control (usual care, n=727), and 14 (n=644) to the intervention. After community screening, the intervention included treatment of cardiovascular disease risk factors by NPHWs using tablet computer-based simplified management algorithms and counselling programmes; free antihypertensive and statin medications recommended by NPHWs but supervised by physicians; and support from a family member or friend (treatment supporter) to improve adherence to medications and healthy behaviours. The primary outcome was the change in Framingham Risk Score 10-year cardiovascular disease risk estimate at 12 months between intervention and control participants. The HOPE 4 trial is registered at ClinicalTrials.gov, NCT01826019. Findings All communities completed 12-month follow-up (data on 97% of living participants, n=1299). The reduction in Framingham Risk Score for 10-year cardiovascular disease risk was −6·40% (95% CI 8·00 to −4·80) in the control group and −11·17% (−12·88 to −9·47) in the intervention group, with a difference of change of −4·78% (95% CI −7·11 to −2·44, p<0·0001). There was an absolute 11·45 mm Hg (95% CI −14·94 to −7·97) greater reduction in systolic blood pressure, and a 0·41 mmol/L (95% CI −0·60 to −0·23) reduction in LDL with the intervention group (both p<0·0001). Change in blood pressure control status (<140 mm Hg) was 69% in the intervention group versus 30% in the control group (p<0·0001). There were no safety concerns with the intervention. Interpretation A comprehensive model of care led by NPHWs, involving primary care physicians and family that was informed by local context, substantially improved blood pressure control and cardiovascular disease risk. This strategy is effective, pragmatic, and has the potential to substantially reduce cardiovascular disease compared with current strategies that are typically physician based. Funding Canadian Institutes of Health Research; Grand Challenges Canada; Ontario SPOR Support Unit and the Ontario Ministry of Health and Long-Term Care; Boehringer Ingelheim; Department of Management of Non-Communicable Diseases, WHO; and Population Health Research Institute.
- PublicaciónAcceso abiertoA novel method for isolation and culture of primary swine gastric epithelial cells(2021-01-06) Bautista-Amorocho, Henry; Silva-Sayago, Jorge Alexander; Goyeneche-Patino, Diego A.; Pérez-Cala, Tania Liseth; Macías-Gómez, Fabio; Arango-Viana, Juan Carlos; Martínez, Alonso; CliniUDESBackground: Culturing primary epithelial cells has a major advantage over tumor-derived or immortalized cell lines as long as their functional phenotype and genetic makeup are mainly maintained. The swine model has shown to be helpful and reliable when used as a surrogate model for human diseases. Several porcine cell lines have been established based on a variety of tissues, which have shown to extensively contribute to the current understanding of several pathologies, especially cancer. However, protocols for the isolation and culture of swine gastric epithelial cells that preserve cell phenotype are rather limited. We aimed to develop a new method for establishing a primary epithelial cell culture from the fundic gland region of the pig stomach. Results: Mechanical and enzymatic dissociation of gastric tissue was possible by combining collagenase type I and dispase II, protease inhibitors and antioxidants, which allowed the isolation of epithelial cells from the porcine fundic glands showing cell viability > 90% during the incubation period. Gastric epithelial cells cultured in RPMI 1640, DMEM-HG and DMEM/F12 media did not contribute enough to cell adhesion, cluster formation and cell proliferation. By contrast, William’s E medium supplemented with growth factors supports confluency and proliferation of a pure epithelial cell monolayer after 10 days of incubation at 37 °C, 5% CO2. Mucin-producing cell phenotype of primary isolates was confirmed by PAS staining, MUC1 by immunohistochemistry, as well as the expression of MUC1 and MUC20 genes by RT-PCR and cDNA sequencing. Swine gastric epithelial cells also showed origin-specific markers such as cytokeratin cocktail (AE1/AE3) and cytokeratin 18 (CK-18) using immunohistochemical and immunofluorescence methods, respectively. Conclusions: A new method was successfully established for the isolation of primary gastric epithelial cells from the fundic gland zone through a swine model based on a combination of tissue-specific proteases, protease inhibitors and antioxidants after mechanical cell dissociation. The formulation of William’s E medium with growth factors for epithelial cells contributes to cell adhesion and preserves functional primary cells phenotype, which is confirmed by mucin production and expression of typical epithelial markers over time.
- PublicaciónAcceso abiertoA pandemia por COVID-19: uma oportunidade para visibilizar a enfermagem em nível internacional(2020-08-28) Torres-Contreras, Claudia Consuelo; Everest
- PublicaciónAcceso abiertoA theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR(Taylor & Francis Group, 2019-09-07) Arndt, Claudia; Feldmann, Anja; Koristka, Stefanie; Schäfer, Martin; Bergmann, Ralf; Mitwasi, Nicola; Berndt, Nicole; Bachmann, Dominik; Kegler, Alexandra; Schmitz, Marc; Puentes-Cala, Edinson; Soto, Javier-Andrés; Ehninger, Gerhard; Pietzsch, Jens; Liolios, Christos; Wunderlich, Gerd; Kotzerke, Jörg; Kopka, Klaus; Bachmann, Michael; Taylor & Francis GroupChimeric antigen receptor (CAR) T cells have shown impressive therapeutic potential. Due to the lack of direct control mechanisms, therapy-related adverse reactions including cytokine release- and tumor lysis syndrome can even become life-threatening. In case of target antigen expression on non-malignant cells, CAR T cells can also attack healthy tissues. To overcome such side effects, we have established a modular CAR platform termed UniCAR: UniCAR T cells per se are inert as they recognize a peptide epitope (UniCAR epitope) that is not accessible on the surface of living cells. Bifunctional adapter molecules termed target modules (TM) can cross-link UniCAR T cells with target cells. In the absence of TMs, UniCAR T cells automatically turn off. Until now, all UniCAR TMs were constructed by fusion of the UniCAR epitope to an antibody domain. To open up the wide field of low-molecular-weight compounds for retargeting of UniCAR T cells to tumor cells, and to follow in parallel the progress of UniCAR T cell therapy by PET imaging we challenged the idea to convert a PET tracer into a UniCAR-TM. For proof of concept, we selected the clinically used PET tracer PSMA-11, which binds to the prostate-specific membrane antigen overexpressed in prostate carcinoma. Here we show that fusion of the UniCAR epitope to PSMA-11 results in a low-molecular-weight theranostic compound that can be used for both retargeting of UniCAR T cells to tumor cells, and for non-invasive PET imaging and thus represents a member of a novel class of theranostics.
- PublicaciónAcceso abiertoAbsence of hepatitis C infection among illegal drug users in Bucaramanga, Colombia(2011-01) Bautista Amorocho, Henry; Jaimes Moreno, Brigitte Zorelly; Hincapié López, Martha-LucíaThe aim of this study was to estimate the prevalence of hepatitis C virus (HCV) and identify risk factors associated with the transmission this virus among drug users. In 2009 we performed a cross-sectional study at three facilities handling cases of drug addiction and in one prison. 259 participants were interviewed to collect socio-demographic information and determine risk factors. Anti-HCV antibodies were identified with two different immunoassays. HCV prevalence was 0%. 98% of participants used illegal drugs either orally or nasally while 4.2% injected drugs. 78% of participants reported marijuana consumption, 51% reported consumption of bazuco (Colombian variant of crack cocaine), 50.2% reported cocaine consumption and 22.8% reported amphetamine consumption. 59% had consumed drugs for more than 5 years, 60.2% had tattoos, 17.8% had piercings, and 84.9% have practiced unsafe sex. HCV prevalence was lower than reported in previous studies of drug users in Latin-America. However, we identified risk factors that would facilitate HCV infection once the virus is introduced in this population.
- PublicaciónAcceso abiertoAceleración del proceso de compostaje de residuos post-cosecha (pulpa) del café con la aplicación de microorganismos nativos(2010) Vásquez de Díaz, María Cristina; López, Andrea; Fuentes, Beatriz; Cote, ElvaColombia, as a leading exporter of coffee smooth, in 2008 produced an average of 12 524 thousand bags of coffee, each 60 kg, of which 3 005 tones are coffee cherry, these large volumes produced post- harvest, are considered contaminants. These products can be used to produce organic fertilizer. The traditional composting process takes about 150 days because of that the decreasing time to 40 days, it is proposed. Isolation of microorganisms from a pre-enrichment in a basal medium cherry Saline (MBS) to obtain axenic cultures, were identified and tested for compatibility between the consortia to select strains tested. Four 4 biopiles were made with a weight of 175 kg each one and one control. They were inoculated by spraying with a concentration of 3 x 107 CFU/mL during 10, 20 and 30 days, with monitoring of physical parameters. They were isolated and identified 8 strains: Pseudomonas aeruginosa, Citrobacter koseri, Bacillus sp, Escherichia coli, Stenotrophomona maltophilia, Cromobacterium spp, Pseudomonas spp. The carbonnitrogen (C/N) ratio in the stack 1 (9.6 %), in the stack 2 (10 %), and the pile 4 (9.5 %) fulfilled the established values (< 20 %), showing maturity and sanitary quality with low levels of fecal coliform and total absence of Salmonella. The results in 40 days allowed a compost that meets the parameters established by the Colombian technical standard (5167 NTC, 2004).
- PublicaciónAcceso abiertoAcoso escolar en adolescentes: rol, tipo de violencia y determinantes(2020-10-26) Paez-Esteban, Astrid Nathalia; Torres-Contreras, Claudia Consuelo; Ortiz-Rodriguez, Sandra Patricia; Campos de Aldana, Maria Stella; Duarte-Bueno, Laura Maria; Nino de Silva, Beatriz Andrea del Pilar; Salud Pública UDESObjetivo Determinar la prevalencia del acoso escolar y sus factores determinantes en adolescentes escolarizados. Método Estudio de corte transversal analítico en una muestra de adolescentes provenientes de 20 instituciones educativas públicas de una ciudad de Colombia, seleccionados mediante un muestreo probabilístico polietápico. Se realizó regresión binomial simple y multivariable. Resultados Participaron 500 adolescentes. El 50,4% eran mujeres y 53,2% en adolescencia media. Predominó la violencia verbal (66,5%) seguida de física (32,0%) y por exclusión (30,6%). El 69,5% de los adolescentes fueron testigos, 35,8% víctimas y 14,2% agresores. El 80,5% de los agresores fueron víctimas de acoso escolar. En el análisis multivariable, se encontró asociación entre ser víctima y presentar alguna discapacidad (RP 2,4 IC 1,6-3,7), agresión verbal en el hogar (RP 1,7 IC 1,2-2,3) y consumo de droga (RP 1,7 IC 1,1-2,8). Asimismo, ser agresor se asoció con ser víctima (RP 7,2 IC 3,6-14,3) y consumo de alcohol (RP 2,2 IC 1,3-3,8). Conclusión La frecuencia de acoso escolar observada y los factores determinantes asociados, evidencian la persistencia de esta problemática en los adolescentes y la necesidad de desarrollar una cultura de convivencia adecuada e incluyente que trascienda el escenario escolar.
- PublicaciónRestringidoLa acreditación de la educación superior colombiana. Balance y perspectivas(2012-01) Almeida Parra, Gloria; Ramírez, TulioSelf-evaluation processes with a view to obtaining qualified registration or accreditation of high quality constitute valuable tools to determine to what extent an institution of higher education has the elements that allow you to be aware of the needs says the company, at a time when it is easier to access information and different ways of acquiring knowledge. It is then appropriate to identify the importance of these processes, in addition to identifying what has been achieved so far in Colombia and which would fail to define or achieve in terms of educational processes.
- PublicaciónAcceso abiertoActinobacteria-enhanced plant growth, nutrient acquisition, and crop protection: Advances in soil, plant, and microbial multifactorial interactions(2022-02-05) Mitra, Debasis; MondaL, Rittick; Khoshru, Bahman; Senapati, Ansuman; Radha, T. K.; Mahakur, Bhaswatimayee; Uniyal, Navendra; Myo, Ei Mon; Boutaj, Hanane; Guerra-Sierra, Beatriz Elena; Panneerselvam, Periyasamy; Ganeshamurthy, Arakalagud Nanjundaiah; Andelković, Snežana; Vasić, Tanja; Rani, Anju; Dutta, Subhadeep; Das Mohapatra, Pradeep K.; MicrobiotaAgricultural areas of land are deteriorating every day owing to population increase, rapid urbanization, and industrialization. To feed today's huge populations, increased crop production is required from smaller areas, which warrants the continuous application of high doses of inorganic fertilizers to agricultural land. These cause damage to soil health and, therefore, nutrient imbalance conditions in arable soils. Under these conditions, the benefits of microbial inoculants (such as Actinobacteria) as replacements for harmful chemicals and promoting ecofriendly sustainable farming practices have been made clear through recent technological advances. There are multifunctional traits involved in the production of different types of bioactive compounds responsible for plant growth promotion, and the biocontrol of phytopathogens has reduced the use of chemical fertilizers and pesticides. There are some well-known groups of nitrogen-fixing Actinobacteria, such as Frankia, which undergo mutualism with plants and offer enhanced symbiotic trade-offs. In addition to nitrogen fixation, increasing availability of major plant nutrients in soil due to the solubilization of immobilized forms of phosphorus and potassium compounds, production of phytohormones, such as indole-3-acetic acid, indole-3-pyruvic acid, gibberellins, and cytokinins, improving organic matter decomposition by releasing cellulases, xylanase, glucanases, lipases, and proteases, and suppression of soil-borne pathogens by the production of siderophores, ammonia, hydrogen cyanide, and chitinase are important features of Actinobacteria useful for combating biotic and abiotic stresses in plants. The positive influence of Actinobacteria on soil fertility and plant health has motivated us to compile this review of important findings associated with sustaining plant productivity in the long run.
- PublicaciónAcceso abiertoActividad Acaricida In Vitro de Compuestos Sobre Schizotetranychus hindustanicus(Hirst), (Acari: Tetranychidae), Ácaro Hindú de los Cítricos(2022-02-01) Ortiz-Meneses, Fredy Alejandro; Guerra-Sierra, Beatriz Elena; Osorio-Alvarado, Carlos Enrique; Rodriguez-Gonzalez, Leidy; MicrobiotaEl cultivo de lima Tahití(Citrus x latifolia Tanaka ex Q. Jiménez)ocupa un importante porcentaje dentro de la cadenacomercialde los cítricos en Colombia, pero es atacado por Schizotetranychus hindustanicus o ácarohindú, un fitófago que produce lesiones típicas en el haz de las hojas y frutos, caracterizadas por manchas blanquecinas circulares que corresponden a las telarañas que teje la hembra y que le restan valor estético al fruto y a su comercialización. El objetivo del presente estudio consistió en evaluar in vitrolos efectos acaricidas de distintos compuestos en tres tiempos de contacto sobre poblaciones del ácaro.Se evaluó extracto oleaginoso de Neem (Azadirachta indica)al 1,0%, azufre micronizado al 0,5%, extracto acuoso de Azadirachtina 0,4%, filtrado de caldo de ceniza al 15 %. Como control positivo se utilizó Abamectina al 0,2%, producto reconocido por su efecto acaricida, y se usó agua destilada como control negativo. Se evidenció que los tratamientos más efectivos fueronelextracto oleaginoso de Neem-A. indicaal1,0%, azufre micronizado al 0,5%, y Abamectina al 0,2% con valores de mortalidad del 96,4;97,9 y100 % a las 72 horasrespectivamente. Los resultados permiten sugerir el uso de compuestos naturales a base de Azadirachta indicaen soluciones oleaginosas para el control deesta plaga, pues no afectan el ecosistema a la vez que no se han reportado resistencias del fitófago por su uso.
- PublicaciónAcceso abiertoActividad antimicrobiana de aceites esenciales de Lippia alba y cymbopogon citratus sobre streptococcus mutans y citotoxicidad en células cho(2016) Ortega Cuadros, Mailen; Tofiño Rivera, Adriana Patricia; Mena Álvarez, O.; Martínez Pabón, M.C.; Galvis Pareja, D.; Merini, Luciano J.Background: Dental caries is a complex in- fectious disease of multifactorial origin in which interactions occur between plaque, tooth, biological determinants such as salivary f low, buffering capa- city and pH of saliva, predominant organisms, diet and behavioral socioeconomic factors; prevails in the 60-90% of the world’s school-age population. The existing prevention and treatment are not com- pletely effective and generate some side effects, so the search for complementary strategies is necessary for handling. Objetives: To evaluate the capabi- lity of essential oils on Lippia alba (Mill). N.E.Br and Cymbopogon citratus (DC.) Stapf to eradicate S. mutans biofilms and its toxicity on eukaryotic cells. Methods: Essential oils were extracted from plant material through steam distillation. Its chemical composition was determined for gas chromato- graphy with mass selective detector (GC-MS). It was used the MBEC-high-throughput technique to determine the removal concentration of S. mu- tans biofilms. Cytotoxicity was evaluated on CHO cells through The MTT 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium. Results: The major components in both essential oils were Geraniol and Citral. Lippia alba essential oil applied in concen- tration of 0.01 mg / 100 mL removed 95.8% of S. mutans biofilm and C. citratus e s s ent i a l o i l s h o w e d a removal activity of 95.4% in the concentrations 0.1, 0.01mg /100 mL and 93.1% in concentration 0.001 mg / 100 mL. None of the essential oils showed toxicity to CHO cells in a 24-hour treatment, with signif icant differences in relation to the control with methanol (P = 0.00) which inhibits most cells. Conclusions: The L. alba and C. citratus essential oils showed eradication activity against S. mutans biof ilms and null cytotoxicity, evidencing a po- tential use in treating and preventing dental caries.
- PublicaciónAcceso abiertoActividades de innovación en servicios en las pequeñas y medianas empresas comerciales del sector textil de Valledupar, Colombia(2016) Pertuz Peralta, Vanessa Paola; Boscan Romero, Neida Coromoto; Straccia Martínez, Daysi Coromoto; Pérez Orozco, Adith BismarckThe article aims to describe the service´s activities of innovation in small and medium enterprises (PYMES) in the textile sector in Valledupar, Colombia. The activities include the knowledge's acquisition and machines, preparations for innovation, market research and training processes. This research is descriptive, a field research, non-experimental and transactional. The CEO answers a Likert questionnaire. The results indicate the predominant activity is the acquisition of machinery. In contrast, there is a low acquisition of knowledge from abroad and preparation to innovate. The conclusions are the suggestion of innovation's plans; market's analyses and diversify sources of knowledge.
- PublicaciónAcceso abiertoAdministración por valores : Estrategia de mejoramiento del clima organizacional en las empresas(2018-04) Gómez Santos, Mónica Patricia; Vidal Tovar, Carlos Ramón; Ureña Villamizar, Yan Carlos; Acevedo Peñaloza, CarlosSe presentan a continuación los resultados de la investigación sobre la Administración por Valores como estrategia de mejoramiento del clima organizacional empresarial en organizaciones localizadas en la ciudad de Valledupar, cuyo objetivo general fue establecer un programa de Administración por Valores como estrategia de mejoramiento del clima organizacional empresarial para lo cual se identificó la situación actual del clima organizacional que presenta la empresa; se determinó los valores que harán parte del programa de Administración por Valores y diseñan estrategias para la implementación de un programa de Administración por Valores. Para lo anterior se desarrolló un diagnóstico de la situación actual del clima organizacional; se establecen las debilidades, fortalezas, amenazas y oportunidades para el diseño e implementación del programa de Administración por Valores. De acuerdo a lo anterior, Existe la necesidad de formar y crear estrategias de compensación, distintas a las económicas, dentro de las empresas, y que se convierten en elementos motivadores y potenciadores de buen clima organizacional; la implementación del programa Administración por valores, permite generar una mejor actitud de parte de todo el personal de las empresas, desde los administrativos, operarios y comerciales, hacia el trabajo y el relacionamiento entre ellos. Además, en las organizaciones se ha generado una cultura de liderazgo y trabajo en equipo mucho más dinámica y espontánea, permitiendo el empoderamiento y la pertenencia hacia la organización.
- PublicaciónAcceso abiertoAdopción del rol maternal de la teorista Ramona Mercer al cuidado de enfermería binomio madre-hijo : Reporte de caso en la unidad materno infantil(2011-01) Alvarado, Laura; Guarín, Luzmila; Cañón Montañez, WilsonIntroducción: Esta propuesta se centra en el papel maternal, donde la madre constituye un proceso de interacción y desarrollo. Cuando la madre logra el apego de su hijo, adquiere experiencia en su cuidado y experimenta la alegría y la gratificación de su papel. Mercer abarca varios factores maternales: edad, estado de salud, relación padre-madre y características del lactante. Además define la forma en que la madre percibe los acontecimientos vividos que influirán al momento de llevar los cuidados a su hijo con características innatas de su personalidad. Materiales y Métodos: Reporte de caso de una Usuaria con 30 años de edad, asiste a la unidad Materno Infantil por control de Ginecobstetricia donde se ordena ecografía obstétrica la cual reporta oligoamnios; es trasladada a cirugía para extracción de producto de sexo masculino por cesárea. En el puerperio tardío presenta dehiscencia de la herida quirúrgica. Resultados: Son diversas las actividades que desarrolla la enfermera para lograr cada vez mas una mejor situación de salud y por ende una mejor calidad de vida, con formación científica cumpliendo de ese modo con los criterios de la atención integral que implican la atención de lo físico, mental y espiritual. Discusión y Conclusiones: Es importante recalcar el cuidado materno perinatal de la profesión de enfermería que ejerce el rol desde diversos campos de acción y en las diferentes etapas de la procreación. La aplicación de esta teoría a la práctica asistencial sirvió como marco para la valoración, planificación, implantación y evaluación del cuidado del binomio madre – hijo, ayudando a simplificar un proceso muy complejo y facilitando su comprensión para la aplicación del mismo en la práctica.
- PublicaciónAcceso abiertoAdvancing the global public health agenda for NAFLD. A consensus statement(Consensus Statement, 2022-01-05) Lazarus, Jeffrey V.; Mark, Henry E.; Anstee, Quentin M.; Arab, Juan Pablo; Batterham, Rachel L.; Castera, Laurent; Cortez-Pinto, Helena; Crespo, Javier; Cusi, Kenneth; Ashworth Dirac, M.; Francque, Sven; George, Jacob; Hagström, Hannes; Huang, Terry T.-K.; Ismail, Mona H.; Kautz, Achim; Kumar Sarin, Shiv; Loomba, Rohit; Miller, Veronica; Newsome, Philip N.; Ninburg, Michael; Ocama, Ponsiano; Ratziu, Vlad; Rinella, Mary; Romero, Diana; Romero-Gómez, Manuel; Schattenberg, Jörn M.; Tsochatzis, Emmanuel A.; Valenti, Luca; Wai-Sun Wong, Vincent; Yilmaz, Yusuf; Younossi, Zobair M.; Zelber-Sagi, Shira; NAFLD Consensus Consortium; Lopez-Jaramillo, Patricio; MasiraNon-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attention from the global public health community. Health system and public health responses to NAFLD have been weak and fragmented, and, despite its pervasiveness, NAFLD is largely unknown outside hepatology and gastroenterology. There is only a nascent global public health movement addressing NAFLD, and the disease is absent from nearly all national and international strategies and policies for non-communicable diseases, including obesity. In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations, which a larger group of collaborators reviewed over three rounds until consensus was achieved. The resulting consensus statements and recommendations address a broad range of topics — from epidemiology, awareness, care and treatment to public health policies and leadership — that have general relevance for policy-makers, health-care practitioners, civil society groups, research institutions and affected populations. These recommendations should provide a strong foundation for a comprehensive public health response to NAFLD.
- PublicaciónAcceso abiertoAerosol box for intubation of patients with suspected COVID-19: simulation study(2021-10-04) Alvarez-Robles, Saul; Torres-Contreras, Claudia Consuelo; Rivera Carvajal, Raquel; Lucigniani-Ariza, Víctor Manuel; Vivas-Garcia, Sonia Margarita; MasiraIntroduction Endotracheal intubation is a procedure associated with a high level of exposure to the COVID-19 virus. This has led to the search of alternatives to reduce the risk of contamination, including the so-called aerosol box. ObjectiveTo compare time and difficulty of orotracheal intubation when using the aerosol box in a simulated setting. Methodology Observational study conducted with the participation of 33 anesthetist physicians and anesthesia residents; groups were compared in terms of time and intubation difficulty using a conventional Macintosh laryngoscope and the McGRATH™ MAC (Medtronic) videolaryngoscope with or without aerosol box. In order to determine performance with the intubation maneuver, crude hazard ratios were estimated, and a Cox multivariate regression model was built, adjusted by anesthetist years of experience and difficulties during the procedure. Results On average, the aerosol box increased intubation time by 7.57 seconds (SD 8.33) when the videolaryngoscope was used, and by 6.62 (SD 5.74) with the Macintosh. Overall, 132 intubations were performed, with 121 successful and 6 failed first-time attempts (4 with the use of the aerosol box); 16 participants (48.48%) reported difficulty handling the box. With the use of the Macintosh, intubation was found to be faster than with the videolaryngoscope (cHR: 1.36 [95% CI 0.64-2.88]; adjusted HR: 2.20 [95% CI 0.73-6.62]). Conclusions The use of the aerosol box and personal protective equipment in a simulation setting hinders the intubation maneuver and may result in protracted execution time.
- PublicaciónRestringidoEl afrocolombiano en los textos escolares colombianos(2010-10) Almeida Parra, Gloria; Ramírez, TulioWe analyzed the textbook illustrations of three Colombians elementary school social studies books in order to determine the presence of discriminatory features from the color of the skin. We developed four analytical categories (gender, occupation, background and clothing) with their respective subcategories. The results demonstrate the presence of images containing discriminatory with respect to the Afrocolombian.